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MDM2 Antibody (phospho-T218)

MDM2 Antibody (phospho-T218) size: 0.08 ml 199

Supplier NJS POLY
Price 199
Size 0.08 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration09% sodium azide, 4 with 0, In 1X PBS pH 7
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenMDM2 (phospho-T218)
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, DB
Recommended dilutionsDot blot: 1:500
NotesTitration of the p-MDM2 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis p-MDM2 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #Q00987
PurityAntigen affinity
Description Overexpression of MDM2 can result in excessive inactivation of tumor protein p53, The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, This protein also affects the cell cycle, This protein has E3 ubiquitin ligase activity, and tumorigenesis through interactions with other proteins, as part of an autoregulatory negative feedback loop, diminishing its tumor suppressor function, including retinoblastoma 1 and ribosomal protein L5, which targets tumor protein p53 for proteasomal degradation, MDM2 is a target of the transcription factor tumor protein p53, apoptosis
ImmunogenThis p-MDM2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pT218 of human MDM2
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the p-MDM2 antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetMDM2 (phospho-T218)
Short nameMDM2 Antibody (phospho-T218)
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameMDM2 (Antibody to) (phosphorilated-T218)
Alternative techniqueantibodies
Identity 6973
Gene MDM2
Long gene name MDM2 proto-oncogene
Synonyms gene name E3 ubiquitin protein ligase , human homolog of, mouse double minute 2, p53 binding protein (mouse) Mdm2 p53 binding protein homolog (mouse) MDM2 proto-oncogene, p53-binding protein Mdm2, transformed 3T3 cell double minute 2
Synonyms HDM2 MGC5370
Locus 12q15
Discovery year 1993-12-10
Entrez gene record 4193
Pubmed identfication 1614537 16905769
RefSeq identity NM_006880
Classification Zinc fingers RANBP2-type
Havana BLAST/BLAT OTTHUMG00000142827

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