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MDM2(Ser186) Antibody

MDM2(Ser186) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameMDM2(Ser186) Primary Polyclonal Antibody
Also known asMDM2(Ser186) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenMDM2 Ser186
SpecificityThis is a highly specific antibody against MDM2 Ser186
Modification(s)Phosphorylation
Modification site(s)Ser186
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range165-210/491
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human MDM2 around the phosphorylation site of Ser186
Gene ID number4193
Swiss ProtQ00987
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Also acts as a ubiquitin ligase E3 toward itself and ARRB1, Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways, Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53, Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation, Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain, Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus, Permits the nuclear export of p53/TP53, Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein, Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation, leading to its degradation by the proteasome, E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names ACTFS, Double minute 2 protein, E3 ubiquitin-protein ligase Mdm2, MDM2, Oncoprotein Mdm2, hdm2, p53-binding protein Mdm2, HDMX
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetMDM2(Ser186)
Short nameMDM2(Ser186) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameMDM2(Ser186) (Antibody to)
Alternative techniqueantibodies
Identity 6973
Gene MDM2
Long gene name MDM2 proto-oncogene
Synonyms gene name E3 ubiquitin protein ligase , human homolog of, mouse double minute 2, p53 binding protein (mouse) Mdm2 p53 binding protein homolog (mouse) MDM2 proto-oncogene, p53-binding protein Mdm2, transformed 3T3 cell double minute 2
Synonyms HDM2 MGC5370
Locus 12q15
Discovery year 1993-12-10
Entrez gene record 4193
Pubmed identfication 1614537 16905769
RefSeq identity NM_006880
Classification Zinc fingers RANBP2-type
Havana BLAST/BLAT OTTHUMG00000142827

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