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MEIS2 Antibody

MEIS2 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameMEIS2 Primary Polyclonal Antibody
Also known asMEIS2 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenMEIS2
SpecificityThis is a highly specific antibody against MEIS2
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MEIS2
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Both Meis1 and Meis2 (also known as Meis-related gene 1 or Mrg1) are members of the TALE (â, Hox proteins are involved in regulating tissue patterning during development, In addition to binding with Hox proteins, In the pancreas, Like Hox and Pbx proteins, Meis1 also forms heterodimers with the ubiquitously expressed Pbx proteins, Meis1 is implicated in oncogenesis, Meis2 and Meis3 (also designated Mrg1 and Mrg2, Meis2 preferentially associates with Pbx1, Pbx and Meis families of transcription factors form heteromeric complexes and bind DNA through specific homeobox domains, Pbx2 and Pbx3, Pdx1, The Hox proteins, Two Meis-related proteins, and are also expressed in lineage- and stage-specific patterns during adult hematopoietic differentiation and in leukemias, and these complexes contain distinct DNA-binding specificities, and together they associate with the pancreas-specific homeodomain factor, as it is overexpressed as a result of adjacent retroviral insertion in BHX-2 myeloid leukemias, have a low intrinsic binding affinity for DNA and are instead associated into cooperative DNA binding complexes with Pbx or the Pbx- related Meis proteins, including Pbx1, possess largely similar sequence identity with Meis1 and are expressed in normal tissues and myeloid leukemias, respectively), to repress Pdx1-induced transcriptional activation, which include paralog groups 1-10, which result in an enhanced Hox-DNA binding affinity and an increased selectivity for the binding site, &euro, &euro, &oelig, Hox, three amino acid loop extensionâ, ) family of homeodomain-containing proteins
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names HsT18361, MEIS2, MEIS2_HUMAN, MGC2820, MRG1, Meis homeobox 2, Meis homolog 2, Meis mouse homolog 2, Meis1 myeloid ecotropic viral integration site 1 homolog 2 antibodyMeis1 related gene 1, Meis1 myeloid ecotropic viral integration site 1 homolog 2 mouse, Meis1 related protein 1, Meis1-related protein 1, TALE homeobox protein Meis2, Homeobox protein Meis2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetMEIS2
Short nameMEIS2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameMEIS2 (Antibody to)
Alternative techniqueantibodies
Identity 7001
Gene MEIS2
Long gene name Meis homeobox 2
Synonyms gene name Meis (mouse) homolog 2 Meis1, myeloid ecotropic viral integration site 1 homolog 2 (mouse)
Synonyms MRG1 HsT18361
Locus 15q14
Discovery year 1998-02-09
GenBank acession AF017418
Entrez gene record 4212
Pubmed identfication 9383298
RefSeq identity NM_170677
Classification TALE class homeoboxes and pseudogenes
Havana BLAST/BLAT OTTHUMG00000129781

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