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MEK1 (32G3) Monoclonal Antibody

MEK1 (32G3) Monoclonal Antibody size: 0.1ml 362

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 362
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameMEK1 (32G3) Monoclonal Antibody
Also known asMEK1 (32G3) Monoclonal Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenMEK1
SpecificityThis is a highly specific antibody against MEK1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone number32G3
SourceRecombinant human protein purified from E, coli(His-MEK1)
Gene ID number5604
Swiss ProtQ02750
Tested ApplicationsWB
Recommended dilutions000), WB (1:2
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Binding of extracellular ligands such as growth factors, Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, Depending on the cellular context, MAP2K1/MEK1 has been shown to export PPARG from the nucleus, One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2, The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, a nuclear receptor that promotes differentiation and apoptosis, adhesion, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, as well as in the fragmentation of the Golgi apparatus during mitosis, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), leading to their activation and further transduction of the signal within the MAPK/ERK cascade, metabolism and cytoskeletal rearrangements, predominantly through the regulation of transcription, survival and differentiation, this pathway mediates diverse biological functions such as cell growth, Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway
Purification methodAmmonium sulfate precipitation
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Dual specificity mitogen-activated protein kinase kinase 1, ERK activator kinase 1, MAP kinase kinase 1, MAP2K1, MAPK/ERK kinase 1, MAPKK 1, MAPKK1, MEK 1, MEK1, MKK1, PRKMK1, CFC3
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene targetMEK1 (32G3) Monoclonal
Short nameMEK1 (32G3) Monoclonal Antibody
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative nameMEK1 (32G3) monoclonal (Antibody to)
Alternative techniqueantibodies
Identity 6840
Gene MAP2K1
Long gene name mitogen-activated protein kinase kinase 1
Synonyms gene PRKMK1
Synonyms MEK1 MAPKK1
Locus 15q22, 31
Discovery year 1993-11-05
GenBank acession L11284
Entrez gene record 5604
Pubmed identfication 9465908 8388392
Classification Mitogen-activated protein kinase kinases
Havana BLAST/BLAT OTTHUMG00000133196
Locus Specific Databases The Globin Gene Server LRG_725

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