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MEK1 Antibody, ALEXA FLUOR 488

MEK1 Antibody, ALEXA FLUOR 488 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 488 Conjugated, MEK1 Polyclonal Antibody
Also known asAnti-MEK1 PAb ALEXA FLUOR 488
CategoryConjugated Primary Antibodies
Conjugated with 488, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenMEK1
SpecificityThis is a highly specific antibody against MEK1
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range2-35/393
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MEK1
Gene ID Number5604
Swiss ProtQ02750
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Binding of extracellular ligands such as growth factors, Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade, Depending on the cellular context, MAP2K1/MEK1 has been shown to export PPARG from the nucleus, One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG), RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2, The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics, a nuclear receptor that promotes differentiation and apoptosis, adhesion, and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2, as well as in the fragmentation of the Golgi apparatus during mitosis, cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC), leading to their activation and further transduction of the signal within the MAPK/ERK cascade, metabolism and cytoskeletal rearrangements, predominantly through the regulation of transcription, survival and differentiation, this pathway mediates diverse biological functions such as cell growth, Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission499nm/519nm
Synonyms MEK1 MAPKK1
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the MEK1 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
ConjugationAlexa Fluor
Gene targetMEK1
Short nameMEK1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 488
Alternative name ALEXA FLUOR 488, MEK1 (Antibody to)
Alternative techniqueantibodies
Identity 6840
Gene MAP2K1
Long gene name mitogen-activated protein kinase kinase 1
Synonyms gene PRKMK1
Locus 15q22, 31
Discovery year 1993-11-05
GenBank acession L11284
Entrez gene record 5604
Pubmed identfication 9465908 8388392
Classification Mitogen-activated protein kinase kinases
Havana BLAST/BLAT OTTHUMG00000133196
Locus Specific Databases The Globin Gene Server LRG_725

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