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MEK6 Antibody, FITC Conjugated

MEK6 Antibody, FITC Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name FITC Conjugated, MEK6 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationAnti-FITC Antibody
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenMEK6
SpecificityThis is a highly specific antibody against MEK6
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range270-320/334
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic peptide derived from human MEK6
Gene ID number5608
Swiss ProtP52564
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Acts also as a regulator for melanocytes dendricity, Especially, Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, MAP2K6/MKK6 also phosphorylates and activates PAK6, MAP2K6/MKK6 mediates apoptotic cell death in thymocytes, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses, Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1, The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors, The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction, With MAP3K3/MKK3, Within the p38 MAPK signal transduction pathway, and for IFNG-dependent gene transcription, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, through the modulation of Rho family GTPases, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF, Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission494nm/518nm
Synonyms MEK6 MKK6 SAPKK3 MAPKK6
Properties Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetMEK6 Conjugated
Short name FITC Conjugated, MEK6 Antibody
Technique Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelFITC
Alternative name fluorecein coupled, MEK6 (Antibody to)
Alternative techniqueantibodies
Identity 6846
Gene MAP2K6
Long gene name mitogen-activated protein kinase kinase 6
Synonyms gene PRKMK6
Synonyms name kinase 6 (MAP kinase kinase 6) , mitogen-activated, protein kinase
Locus 17q24, 3
Discovery year 1997-11-11
GenBank acession U39064
Entrez gene record 5608
Pubmed identfication 8621675
RefSeq identity NM_002758
Classification Mitogen-activated protein kinase kinases
Havana BLAST/BLAT OTTHUMG00000180311

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