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MEK6 (MAP kinase kinase 6) (AF8B6) Monoclonal Antibody

MEK6 (MAP kinase kinase 6) (AF8B6) Monoclonal Antibody size: 0.1ml 362

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 362
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameMEK6 (MAP kinase kinase 6) (AF8B6) Monoclonal Antibody
Also known asMEK6 (MAP kinase kinase 6) (AF8B6) Monoclonal Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenMEK6 (MAP kinase kinase 6)
SpecificityThis is a highly specific antibody against MEK6 (MAP kinase kinase 6)
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone numberAF8B6
Concentration2ug/ul
SourceRecombinant human protein purified from E, coli (His-MEK6)
Gene ID number5608
Swiss ProtP52564
Tested Applications IP, WB
Recommended dilutions0 ug/ml) IP (2 ug), WB (2
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Acts also as a regulator for melanocytes dendricity, Especially, Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, MAP2K6/MKK6 also phosphorylates and activates PAK6, MAP2K6/MKK6 mediates apoptotic cell death in thymocytes, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses, Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1, The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors, The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction, With MAP3K3/MKK3, Within the p38 MAPK signal transduction pathway, and for IFNG-dependent gene transcription, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, through the modulation of Rho family GTPases, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF, Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway
Purification methodPurified by Protein G
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Dual specificity mitogen-activated protein kinase kinase 6, MAP kinase kinase 6, MAP2K6, MAPK/ERK kinase 6, MAPKK 6, MAPKK6, MEK 6, MKK6, PRKMK6, SAPK kinase 3, SAPKK-3, SAPKK3, SKK3, Stress-activated protein kinase kinase 3, MEK6
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene targetMEK6 (MAP kinase kinase 6) (AF8B6) Monoclonal
Short nameMEK6 (MAP kinase kinase 6) (AF8B6) Monoclonal Antibody
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative nameMEK6 (mitogen-stimulated protein kinase phosphorylation catalyst kinase 6) (AF8B6) monoclonal (Antibody to)
Alternative techniqueantibodies
Identity 6846
Gene MAP2K6
Long gene name mitogen-activated protein kinase kinase 6
Synonyms gene PRKMK6
Synonyms MEK6 MKK6 SAPKK3 MAPKK6
Synonyms name kinase 6 (MAP kinase kinase 6) , mitogen-activated, protein kinase
Locus 17q24, 3
Discovery year 1997-11-11
GenBank acession U39064
Entrez gene record 5608
Pubmed identfication 8621675
RefSeq identity NM_002758
Classification Mitogen-activated protein kinase kinases
Havana BLAST/BLAT OTTHUMG00000180311

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