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MEK7 Antibody / MAP2K7 / MKK7

MEK7 Antibody / MAP2K7 / MKK7 size: 0.1mg 406

Supplier NJS POLY
Price 406
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenMEK7 / MAP2K7 / MKK7
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications IHC-P, WB
Recommended dilutions1-0, 5-1ug/ml, 5ug/ml, IHC (Paraffin): 0, Western blot: 0
NotesOptimal dilution of the MKK7 antibody should be determined by the researcher
Intented useThis MKK7 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #O14733
PurityAntigen affinity
Description Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway, Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines, MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue, MAPK9/JNK2 and MAPK10/JNK3, The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, With MAP2K4/MKK4, [UniProt], but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif, including the release cytochrome c, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, leading to apoptosis, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation, Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway
ImmunogenAmino acids AASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPR of human MAP2K7 were used as the immunogen for the MKK7 antibody
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the MKK7 antibody may be kept for up to one month refrigerated at +4 degrees C, After reconstitution, For long-term
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetMEK7 / MAP2K7 / MKK7
Short nameMEK7 Antibody / MAP2K7 / MKK7
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameMEK7 (Antibody to) / MAP2K7 / MKK7
Alternative techniqueantibodies
Identity 6847
Gene MAP2K7
Long gene name mitogen-activated protein kinase kinase 7
Synonyms gene PRKMK7
Synonyms MKK7 Jnkk2
Locus 19p13, 2
Discovery year 1998-04-28
GenBank acession AF006689
Entrez gene record 5609
Pubmed identfication 9312068
Classification Mitogen-activated protein kinase kinases
Havana BLAST/BLAT OTTHUMG00000137368

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