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MELK/HPK38 Antibody

MELK/HPK38 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameMELK/HPK38 Primary Polyclonal Antibody
Also known asMELK/HPK38 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenMELK/HPK38
SpecificityThis is a highly specific antibody against MELK/HPK38
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range130-180/651
Subcellular locationCell membrane
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MELK/HPK38
Gene ID number9833
Swiss ProtQ14680
Tested Applications IF(IHC-P), IHC-P
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Acts as a regulator of cell cycle, Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1, Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, CDC25B, Has a broad substrate specificity, MAP3K5/ASK1 and ZNF622, May also play a role in primitive hematopoiesis, Phosphorylates and inhibits BCL2L14, Plays a key role in cell proliferation and carcinogenesis, Required for proliferation of embryonic and postnatal multipotent neural progenitors, apoptosis and splicing regulation, notably by mediating phosphorylation of CDC25B, phosphorylates BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis, self-renewal of stem cells, thereby contributing to its redirection to the nucleus, Serine/threonine-protein kinase involved in various processes such as cell cycle regulation
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names KIAA175, MELK, Maternal embryonic leucine zipper kinase, Protein kinase Eg3, Protein kinase PK38, Tyrosine-protein kinase MELK, hMELK, pEg3 kinase, HPK38
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetMELK/HPK38
Short nameMELK/HPK38 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameMELK/HPK38 (Antibody to)
Alternative techniqueantibodies
Identity 16870
Gene MELK
Long gene name maternal embryonic leucine zipper kinase
Synonyms KIAA0175
Locus 9p13, 2
Discovery year 2003-02-04
GenBank acession D79997
Entrez gene record 9833
Pubmed identfication 8724849 9136115
RefSeq identity NM_014791
Havana BLAST/BLAT OTTHUMG00000019906

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