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Mib1/Mindbomb Antibody

Mib1/Mindbomb Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameMib1/Mindbomb Primary Polyclonal Antibody
Also known asMib1/Mindbomb PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenMib1/Mindbomb
SpecificityThis is a highly specific antibody against Mib1/Mindbomb
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Mib1/Mindbomb
Gene ID number57534
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Although it seems to be widely expressed at low levels, Both DAPK and MIB1 are overexpressed in epileptic brain tissue, Delta, MIB1 also interacts with DAPK, MIB1 is expressed at highest concentrations in the CNS and ovary, MIB1 ubiquinates Delta by binding to its intracellular domain, Ubiquination of DAPK leads to inhibition of caspase-dependent apoptosis, a protein that plays an important role in the regulation of apoptosis, leading to the endocytosis and eventual degradation of the Delta receptor, paradoxically, results in the up-regulation of receptor activity and enhances Notch signaling, suggesting that they probably cooperate as regulators of neuronal death in epilepsy, therefore it is likely that overexpression of MIB1 can lead to tumor growth, which, MIB1 is a 1006 amino acid E3 ubiquitin ligase that activates the Notch ligand
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names DIP-1, Dip 1, Dip1, E3 ubiquitin protein ligase MIB 1, E3 ubiquitin protein ligase MIB1, E3 ubiquitin-protein ligase mib1, MIB1_HUMAN, Mind bomb homolog 1, Zinc finger ZZ type with ankyrin repeat domain protein 2, mib1, DAPK-interacting protein 1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetMib1/Mindbomb
Short nameMib1/Mindbomb Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namemindbomb E3 ubiquitin protein ligase 1/Mindbomb (Antibody to)
Alternative techniqueantibodies

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