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Microcephalin 1/BRIT1 Antibody

Microcephalin 1/BRIT1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameMicrocephalin 1/BRIT1 Antibody
Also known asMicrocephalin 1/BRIT1 Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenMicrocephalin 1/BRIT1
SpecificityThis is a highly specific antibody against Microcephalin 1/BRIT1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Microcephalin 1/BRIT1
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Human Microcephalin contains three BRCA1 C-terminal (BRCT) domains and shares 57% identity with its mouse ortholog, It functions in DNA damage response and regulation of cell cycle checkpoints, Microcephalin displays significantly higher rates of protein evolution in primates than in rodents, Microcephalin has a very young, Predominant expression of human Microcephalin is observed in fetal brain, although the nature of the positive selection is poorly understood, liver and kidney tissues and is expressed during neurogenesis in mice, polymorphism haplotype associated with modern humans, single nucleotide, the most conserved regions being BRCT domains where there is 80% identity, this gene is presumably still evolving in Homo sapiens, this trend is most noticeable for the subset of genes associated with nervous system development, Microcephalin modulates brain size and has been proliferating under strong positive selection for several thousand years
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names BRIT 1, FLJ12847, Hypothetical protein FLJ12847, MCPH 1, MCPH1, MCPH1_HUMAN, MCT antibody Microcephalin 1, Microcephalin-1, Microcephaly primary autosomal recessive 1, BRCT repeat inhibitor of TERT expression 1
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetMicrocephalin 1/BRIT1
Short nameMicrocephalin 1/BRIT1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameMicrocephalin 1/BRIT1 (Antibody to)
Alternative techniqueantibodies
Identity 6954
Gene MCPH1
Long gene name microcephalin 1
Synonyms gene name microcephaly, primary autosomal recessive 1
Synonyms FLJ12847 BRIT1
Synonyms name BRCT-repeat inhibitor of TERT expression 1
Locus 8p23, 1
Discovery year 1998-02-11
GenBank acession AK022909
Entrez gene record 79648
Pubmed identfication 9683597 17925396
RefSeq identity NM_024596
Havana BLAST/BLAT OTTHUMG00000163618

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