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MITF Antibody, FITC Conjugated

MITF Antibody, FITC Conjugated size: 0.1ml 333

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 333
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name FITC Conjugated, MITF Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationAnti-FITC Antibody
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenMITF
SpecificityThis is a highly specific antibody against MITF
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range350-400/526
Subcellular locationNucleus
SourceKLH conjugated synthetic peptide derived from human MITF
Gene ID number4286
Swiss ProtO75030
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Binds to symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, Plays a critical role in the differentiation of various cell types, Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1), mast cells, osteoclasts and optic cup-derived retinal pigment epithelium, proliferation and survival, such as BCL2 and tyrosinase (TYR), such as neural crest-derived melanocytes, Transcription factor that regulates the expression of genes with essential roles in cell differentiation
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission494nm/518nm
Synonyms MI bHLHe32
Properties Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetMITF Conjugated
Short name FITC Conjugated, MITF Antibody
Technique Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelFITC
Alternative name fluorecein coupled, microphthalmia-associated transcription factor (Antibody to)
Alternative techniqueantibodies
Alternative to gene target BT, DNA-templated and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0006461 and protein complex assembly and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0016055 and Wnt signaling pathway and biological process this GO :0030154 and cell differentiation and biological process this GO :0030316 and osteoclast differentiation and biological process this GO :0030318 and melanocyte differentiation and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0043010 and camera-type eye development and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043234 and protein complex and cellular component this GO :0043473 and pigmentation and biological process this GO :0044336 and canonical Wnt signaling pathway involved in negative regulation of apoptotic process and biological process this GO :0045165 and cell fate commitment and biological process this GO :0045670 and regulation of osteoclast differentiation and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0046849 and bone remodeling and biological process this GO :0046983 and protein dimerization activity and molecular function, MITF and IDBG-44086 and ENSG00000187098 and 4286, Mitf and IDBG-172461 and ENSMUSG00000035158 and 17342, bHLHe32 and CMM8 and MI and WS2 and WS2A, nuclei, protein dimerization activity, this GO :0000978 and RNA polymerase II core promoter proximal region sequence-specific DNA binding and molecular function this GO :0000979 and RNA polymerase II core promoter sequence-specific DNA binding and molecular function this GO :0001077 and RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and molecular function this GO :0003677 and DNA binding and molecular function this GO :0003682 and chromatin binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0003705 and RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0006355 and regulation of transcription, this GO :0000978: RNA polymerase II core promoter proximal region sequence-specific DNA binding, this GO :0000978: RNA polymerase II core promoter proximal region sequence-specific DNA binding and also this GO :0000979: RNA polymerase II core promoter sequence-specific DNA binding and also this GO :0001077: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription and also this GO :0003677: DNA binding and also this GO :0003682: chromatin binding and also this GO :0003700: sequence-specific DNA binding transcription factor activity and also this GO :0003705: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity and also this GO :0005515: protein binding and also this GO :0046983: protein dimerization activity, this GO :0000979: RNA polymerase II core promoter sequence-specific DNA binding, this GO :0001077: RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription, this GO :0003677: DNA binding, this GO :0003682: chromatin binding, this GO :0003700: sequence-specific DNA binding transcription factor activity, this GO :0003705: RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity, this GO :0005515: protein binding, this GO :0046983: protein dimerization activity, 29882 and IDBG-644985 and ENSBTAG00000006679 and 407219, microphthalmia-associated transcription factor
Identity 7105
Gene MITF
Long gene name melanogenesis associated transcription factor
Synonyms gene WS2A WS2
Synonyms gene name Waardenburg syndrome, type 2A microphthalmia-associated transcription factor
Synonyms name homolog of mouse microphthalmia
Locus 3p13
Discovery year 1993-10-27
Entrez gene record 4286
Pubmed identfication 8069297 7874167 7951321
RefSeq identity NM_198159
Classification Basic helix-loop-helix proteins
Havana BLAST/BLAT OTTHUMG00000149921
Locus Specific Databases LOVD - Leiden Open Variation Database LRG_776

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