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MKK7/ERK7 Antibody

MKK7/ERK7 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameMKK7/ERK7 Primary Polyclonal Antibody
Also known asMKK7/ERK7 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenMKK7/ERK7
SpecificityThis is a highly specific antibody against MKK7/ERK7
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range300-350/419
Subcellular location Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MKK7
Gene ID number5609
Swiss ProtO14733
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway, Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines, MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue, MAPK9/JNK2 and MAPK10/JNK3, The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, With MAP2K4/MKK4, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif, including the release cytochrome c, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, leading to apoptosis, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation, Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Dual specificity mitogen-activated protein kinase kinase 7, JNK kinase 2, JNK-activating kinase 2, JNKK 2, JNKK2, MAP kinase kinase 7, MAP2K7, MAPK/ERK kinase 7, MAPKK 7, MAPKK7, MEK 7, MEK7, MKK7, PRKMK7, SAPK kinase 4, SAPKK-4, SAPKK4, SKK4, Stress-activated protein kinase kinase 4, c-Jun N-terminal kinase kinase 2, MEK
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetMKK7/ERK7
Short nameMKK7/ERK7 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameMKK7/ERK7 (Antibody to)
Alternative techniqueantibodies
Identity 6847
Gene MAP2K7
Long gene name mitogen-activated protein kinase kinase 7
Synonyms gene PRKMK7
Synonyms MKK7 Jnkk2
Locus 19p13, 2
Discovery year 1998-04-28
GenBank acession AF006689
Entrez gene record 5609
Pubmed identfication 9312068
Classification Mitogen-activated protein kinase kinases
Havana BLAST/BLAT OTTHUMG00000137368

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