| Also known as | CD40 |
| Other names | B-cell surface antigen CD40, B-cell surface antigen CD40, CD40 molecule, CD40L receptor, CD40L receptor, TNF receptor superfamily member 5<, Tumor necrosis factor receptor superfamily member 5, member 5, tumor necrosis factor receptor superfamily, tumor necrosis factor receptor superfamily member 5, tumor necrosis factor receptor superfamily member 5 |
| Category | Antibodies |
| Subcategory | Mnoclonal antibodies |
| Gene name | CD40 |
| Gene name synonims | N/A |
| Other gene names | CD40, TNFRSF5, TNFRSF5, CD40 |
| Clonality | Monoclonal |
| Immunoglobulin isotype | IgG1 |
| Clone | IL-A156 |
| Host organism | Mouse (Mus musculus) |
| Species reactivity | Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Bovine |
| Specificity and cross-reactivity | Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_CD40 plays an important role in the differentiation of B lymphocytes into effector cells, and is also involved in interactions between T and B lymphocytes, which is expressed by B lymphocytes and a subset of T lymphocytes, CD40 Clone IL-A156 recognises the bovine CD40 cell surface antigen |
| Purification method | N/A |
| Form/Appearance | FITC (Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid) |
| Concentration | 1 miligram per 1 mililiter, IgG concentration 0 |
| Storage and shipping | If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody is photosensitive and should be protected from light, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications: | Flow Cytometry (FACS) |
| Properties | FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, MBS mono FITC is highly sensitive to pH extremes, This MBS mono Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Conjugation | Anti-FITC Antibody |
| Gene target | CD40: |
| Short name | MOUSE Anti-BOVINE CD40:FITC Antibody |
| Technique | Fluorescein, antibodies against human proteins, antibodies for, Antibody |
| Label | FITC |
| Alternative name | tumor necrosis factor receptor superfamily member 5:fluorecein (Antibody to), MOUSE antibody to-BOVINE CD40 molecule |
| Alternative technique | antibodies |
| Alternative to gene target | BT, Bp50 and CDW40 and p50 and TNFRSF5, CD40 and IDBG-78904 and ENSG00000101017 and 958, Cd40 and IDBG-212533 and ENSMUSG00000017652 and 21939, Extracellular, TNF receptor superfamily member 5, this GO :0001934 and positive regulation of protein phosphorylation and biological process this GO :0002768 and immune response-regulating cell surface receptor signaling pathway and biological process this GO :0003823 and antigen binding and molecular function this GO :0004871 and signal transducer activity and molecular function this GO :0004872 and receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006461 and protein complex assembly and biological process this GO :0006874 and cellular calcium ion homeostasis and biological process this GO :0006954 and inflammatory response and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0019899 and enzyme binding and molecular function this GO :0030168 and platelet activation and biological process this GO :0030890 and positive regulation of B cell proliferation and biological process this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0032735 and positive regulation of interleukin-12 production and biological process this GO :0032855 and positive regulation of Rac GTPase activity and biological process this GO :0035631 and CD40 receptor complex and cellular component this GO :0042100 and B cell proliferation and biological process this GO :0042113 and B cell activation and biological process this GO :0042511 and positive regulation of tyrosine phosphorylation of Stat1 protein and biological process this GO :0043089 and positive regulation of Cdc42 GTPase activity and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0043406 and positive regulation of MAP kinase activity and biological process this GO :0045087 and innate immune response and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048304 and positive regulation of isotype switching to IgG isotypes and biological process this GO :0050776 and regulation of immune response and biological process this GO :0051023 and regulation of immunoglobulin secretion and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process this GO :0051607 and defense response to virus and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071222 and cellular response to lipopolysaccharide and biological process this GO :0071260 and cellular response to mechanical stimulus and biological process this GO :0090037 and positive regulation of protein kinase C signaling and biological process this GO :2000353 and positive regulation of endothelial cell apoptotic process and biological process, this GO :0003823: antigen binding, this GO :0003823: antigen binding and also this GO :0004871: signal transducer activity and also this GO :0004872: receptor activity and also this GO :0005515: protein binding and also this GO :0019899: enzyme binding and also this GO :0031625: ubiquitin protein ligase binding, this GO :0004871: signal transducer activity, this GO :0004872: receptor activity, this GO :0005515: protein binding, this GO :0019899: enzyme binding, this GO :0031625: ubiquitin protein ligase binding, ubiquitin protein ligase binding, 42498 and IDBG-643036 and ENSBTAG00000020736 and 286849, CD40 molecule |
| Identity | 11919 |
| Gene | CD40 |
| Long gene name | CD40 molecule |
| Synonyms gene | TNFRSF5 |
| Synonyms gene name | TNF receptor superfamily member 5 , member 5 CD40 molecule, tumor necrosis factor receptor superfamily |
| Synonyms | p50 Bp50 |
| Locus | 20q13, 12 |
| Discovery year | 1993-08-27 |
| GenBank acession | X60592 |
| Entrez gene record | 958 |
| Pubmed identfication | 7687385 2998589 |
| RefSeq identity | NM_001250 |
| Classification | CD molecules Tumor necrosis factor receptor superfamily |
| Havana BLAST/BLAT | OTTHUMG00000033053 |
| Locus Specific Databases | CD40base: Mutation registry for CD40 deficiency (previously known as TNFRSF5base) LRG_40 |
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