MOUSE Anti-HUMAN CD279:RPE Antibody

MOUSE Anti-HUMAN CD279:RPE Antibody size: 100 Tests 475

Price 475

Size 100 Tests

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Also known as	CD279
Other names	N/A, Programmed cell death protein 1, programmed cell death 1, programmed cell death protein 1, protein PD-1, programmed cell death protein 1
Category	Antibodies
Subcategory	Mnoclonal antibodies
Gene name	CD279
Gene name synonims	N/A
Other gene names	CD279, PD-1, PD1, PD1, PDCD1, Protein PD-1, SLEB2, hPD-1, hPD-1, hPD-l, PDCD1
Clonality	Monoclonal
Immunoglobulin isotype	IgG1
Clone	MIH4
Host organism	Mouse (Mus musculus)
Species reactivity	Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens)
Specificity and cross-reactivity	B-cells, CD274 (PD-L1) and CD273 (PD-L2), CD279 has two specific ligands, CD279 is 50-55kD membrane protein which is a member of the CD28 family, CD279 is inducibly expressed by T-cells, NK-T-cells and monocytes upon activation, Recent studies suggest that CD279 could be targeted therapeutically in the treatment of HIV infection to reduce T-cell exhaustion, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_Loss of CD279 function has been associated with a number of autoimmune diseases, a co-stimulatory molecule also known as programmed cell death-1 (PD-1), and functions mainly as a negative regulator of T-cell activation, and their interaction is key in the balance between stimulatory and inhibitory signals needed for effective immune responses to microbes and self-tolerance, including rheumatoid arthritis, type I diabetes and ankylosing spondylitis, CD279 This item detects CD279
Purification method	N/A
Form/Appearance	Phycoerythrin (RPE) - lyophilised), RPE (Purified IgG conjugated to R
Concentration	N/A
Storage and shipping	DO NOT FREEZE, If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Shelf Life: 18 months from date of reconstitution, Temperature variations in the range between +1C to +7C are tolerable, the antibody is photosensitive and should be protected from light, the antibody should be stored undiluted, Keep the antibody refrigerated at +4 degrees Celsius
Tested applications:	Flow Cytometry (FACS)
Properties	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°
Gene target	CD279:RPE
Short name	MOUSE Anti-HUMAN CD279:RPE Antibody
Technique	antibodies against human proteins, antibodies for, Antibody
Alternative name	sapiens CD279:RPE (Antibody to), MOUSE antibody to-H
Alternative technique	antibodies
Identity	8760
Gene	PDCD1
Long gene name	programmed cell death 1
Synonyms gene	SLEB2
Synonyms gene name	systemic lupus erythematosus susceptibility 2
Synonyms	CD279 PD1 hSLE1 PD-1
Locus	2q37, 3
Discovery year	1994-05-24
GenBank acession	AY206416
Entrez gene record	5133
Pubmed identfication	7851902 12402038
RefSeq identity	NM_005018
Classification	CD molecules V-set domain containing
Havana BLAST/BLAT	OTTHUMG00000151342

MOUSE Anti-HUMAN CD279:RPE Antibody

MOUSE Anti-HUMAN CD279:RPE Antibody size: 100 Tests 475

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