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MOUSE Anti-HUMAN CYTOCHROME B245 LIGHT CHAIN Antibody

MOUSE Anti-HUMAN CYTOCHROME B245 LIGHT CHAIN Antibody size: 200ug 531

Supplier MBS MONO
Price 531
Size 200ug
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Also known asCYTOCHROME B245
Other names Cytochrome b(558) alpha chain, Cytochrome b-245 light chain, Cytochrome b558 subunit alpha, Neutrophil cytochrome b 22 kDa polypeptide, Superoxide-generating NADPH oxidase light chain subunit, alpha polypeptide, alpha polypeptide, cytochrome b, cytochrome b light chain, cytochrome b(558) alpha chain, cytochrome b(558) alpha-subunit, cytochrome b-245, cytochrome b-245 light chain, cytochrome b558 subunit alpha, flavocytochrome b-558 alpha polypeptide, neutrophil cytochrome b 22 kDa polypeptide, p22 phagocyte B-cytochrome, p22 phagocyte B-cytochrome, p22-phox, p22phox, superoxide-generating NADPH oxidase light chain subunit, cytochrome b-245 light chain
CategoryAntibodies
SubcategoryMnoclonal antibodies
Gene name CYBA, p22-PHOX, p22phox, CYBA
Gene name synonims CYBA, p22-PHOX, p22phox, CYBA
Other gene names CYBA, p22-PHOX, p22phox, CYBA
ClonalityMonoclonal
Immunoglobulin isotypeIgG1
CloneCS9
Host organismMouse (Mus musculus)
Species reactivity Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens)
Specificity and cross-reactivity Clone CS9 also has an inhibitory effect on NADPH oxidase activation, Cytochrome B245 appears to serve as a scaffold for the assembly of the other cytosolic units of the oxidase and to provide a transmembrane pathway for electrons, Individuals with defects in NADPH oxidase suffer from chronic granulomatous disease, NADPH oxidase is a membrane-bound enzyme complex in neutrophils that produces the superoxide anion (O<, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, Superoxide is used for the destruction of pathogens, This particular antibody might cross react with speacies outside of the listed ones, Upon the appropriate stimulus, _x000D__x000D_The core region of the CS9 epitope is amino acids 165 - 169 (KKPSE), _x000D__x000D_The light chain (p22phox), a cytosolic epitope on p22phox not accessible on intact neutrophils, a subunit of the nicotinamide adenine dinucleotide phosphate-oxidase (NADPH oxidase), along with the heavy chain (gp91phox) form cytochrome B245 (also known as flavocytochome b, also known as p22phox, characterised by severe recurrent infections, or Cyt b), other components of NADPH oxidase (p47phox, p40phox, p67phox and Rac2) rapidly translocate from the cytosol to the cell membrane to form the complete enzyme complex, which is always membrane-resident, <, ) by transferring single electrons from NADPH inside the cell across the membrane and coupling them to molecular oxygen, -<, /sub>, /sup>, 2<, CYTOCHROME B245 This item recognises the light chain of cytochrome B245, sub>, sup>
Purification methodN/A
Form/AppearancePurified (Purified IgG - liquid)
Concentration0mg/ml, IgG concentration 1
Storage and shipping If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term
Tested applications: Flow Cytometry (FACS), Immunohistology - Frozen (IHC), Immunoprecipitation (IP), Western Blot (WB), ELISA (EIA)
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°
Gene targetCYTOCHROME B245 LIGHT CHAIN
Short nameMOUSE Anti-HUMAN CYTOCHROME B245 LIGHT CHAIN Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative name sapiens CYTOCHROME B245 LIGHT epitope (Antibody to), MOUSE antibody to-H
Alternative techniqueantibodies
Identity 11930
Gene TNFSF14
Long gene name tumor necrosis factor superfamily member 14
Synonyms gene name member 14 , tumor necrosis factor (ligand) superfamily
Synonyms LIGHT LTg HVEM-L CD258
Locus 19p13, 3
Discovery year 1998-12-04
GenBank acession AF036581
Entrez gene record 8740
Pubmed identfication 9462508
Classification Tumor necrosis factor superfamily CD molecules
Havana BLAST/BLAT OTTHUMG00000181835

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