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MOUSE Anti-HUMAN MICA/MICB:Biotin Antibody

MOUSE Anti-HUMAN MICA/MICB:Biotin Antibody size: 100ug 486

Supplier MBS MONO
Price 486
Size 100ug
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Also known asMICA/MICB
Other names HLA class I antigen, MHC class I chain-related protein A, MHC class I polypeptide-related sequence A, MHC class I polypeptide-related sequence A, MHC class I polypeptide-related sequence A, N/A, stress inducible class I homolog, MHC class I polypeptide-related sequence A isoform 1 (MICA*001)
CategoryAntibodies
SubcategoryMnoclonal antibodies
Gene nameMICA/MICB
Gene name synonimsN/A
Other gene names MIC-A, MIC-A, MICA, PERB11, PERB11, 1, 1, MICA
ClonalityMonoclonal
Immunoglobulin isotypeIgG2a
Clone6D4
Host organismMouse (Mus musculus)
Species reactivity Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens)
Specificity and cross-reactivity CD8 T cells and gamma delta T cells, Clone 6D4 is reported to inhibit the cytotoxicity of NK cells stimulated by IFN alpha-treated dendritic cells, Expression may be induced to high surface levels by heat shock, MICA and MICB are ligands for NKG2D, MICA and MICB are stress inducible antigens, MICA is principally expressed on intestinal epithelium, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, an activating receptor on most natural killer (NK) cells, and several epithelial tumours, and virus infection, oxidative stress, which are closely related and appear functionally indistinguishable, MICA/MICB This item is specific for nonclassical MHC class I chain A (MICA) and nonclassical MHC class I chain MICB (MICB)
Purification methodN/A
Form/AppearanceBiotin (Purified IgG conjugated to Biotin - liquid)
Concentration1 miligram per 1 mililiter, IgG concentration 0
Storage and shipping If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term
Tested applications: Immunohistology - Frozen (IHC), Flow Cytometry (FACS)
Properties Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°
ConjugationBiotinylated
Gene targetMICA/MICB:
Short nameMOUSE Anti-HUMAN MICA/MICB: Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelBiotin
Alternative name sapiens Major histocompabitility complex class I polypeptide-related sequence A/Major histocompabitility complex class I polypeptide-related sequence B:biotinilated (Antibody to), MOUSE antibody to-H
Alternative techniqueantibodies
Alternative to gene target Cell surfaces, MHC class I polypeptide-related sequence B, MICA and IDBG-77578 and ENSG00000204520 and 100507436, MICB and IDBG-77697 and ENSG00000204516 and 4277, PERB11, Plasma membranes, natural killer cell lectin-like receptor binding, protein binding, this GO :0002429 and immune response-activating cell surface receptor signaling pathway and biological process this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0006955 and immune response and biological process this GO :0006979 and response to oxidative stress and biological process this GO :0009408 and response to heat and biological process this GO :0009986 and cell surface and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016032 and viral process and biological process this GO :0019835 and cytolysis and biological process this GO :0019882 and antigen processing and presentation and biological process this GO :0032526 and response to retinoic acid and biological process this GO :0046629 and gamma-delta T cell activation and biological process this GO :0046703 and natural killer cell lectin-like receptor binding and molecular function this GO :0050689 and negative regulation of defense response to virus by host and biological process this GO :0050776 and regulation of immune response and biological process, this GO :0005515 and protein binding and molecular function this GO :0006955 and immune response and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0019882 and antigen processing and presentation and biological process this GO :0045087 and innate immune response and biological process, this GO :0005515: protein binding, this GO :0005515: protein binding, this GO :0005515: protein binding, this GO :0005515: protein binding and also this GO :0046703: natural killer cell lectin-like receptor binding, this GO :0046703: natural killer cell lectin-like receptor binding, 2, MHC class I polypeptide-related sequence A
Identity 7090
Gene MICA
Long gene name MHC class I polypeptide-related sequence A
Synonyms PERB11, 1
Locus 6p21, 33
Discovery year 1994-05-16
GenBank acession L14848
Entrez gene record 100507436
Pubmed identfication 8022771
RefSeq identity NM_001177519
Classification C1-set domain containing
Havana BLAST/BLAT OTTHUMG00000031073
Locus Specific Databases IMGT/HLA Database

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