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MOUSE Anti-HUMAN PAG Antibody

MOUSE Anti-HUMAN PAG Antibody size: 100ug 393

Supplier MBS MONO
Price 393
Size 100ug
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Also known asPAG
Other names Csk-binding protein, Csk-binding protein, Phosphoprotein associated with glycosphingolipid-enriched microdomains 1, Transmembrane adapter protein PAG, Transmembrane phosphoprotein Cbp, phosphoprotein associated with glycosphingolipid microdomains 1, phosphoprotein associated with glycosphingolipid-enriched microdomains 1, transmembrane adapter protein PAG, transmembrane adaptor protein PAG, transmembrane phosphoprotein Cbp, phosphoprotein associated with glycosphingolipid-enriched microdomains 1
CategoryAntibodies
SubcategoryMnoclonal antibodies
Gene namePAG
Gene name synonimsN/A
Other gene names CBP, CBP, PAG, PAG, PAG1, PAG1
ClonalityMonoclonal
Immunoglobulin isotypeIgG2a
CloneMEM-255
Host organismMouse (Mus musculus)
Species reactivity Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens)
Specificity and cross-reactivity PAG acts not only acts as a 'co-factor' for relocating csk to substrate rich microdomains, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, _x000D_The transmission of signals along the various pathways within this cascade requires the phosphorylation of various substrates, _x000D__x000D_Evidence has shown that by binding to the SH2 domain of the PTK csk, _x000D__x000D_The engagement of immunoreceptors with natural ligands or antibodies is the initiating factor in a long line of events down a cytosolic signaling cascade, _x000D_an epitope (aa 235-280) located in the cytoplasmic domain of csk-binding protein (Cbp), a major negative regulator of src-family kinases, but also increases the affinity of csk for src-family kinases, by members of the src and syk families of protein tyrosine kinases (PTKs), through the formation of PAG-csk complexes, which localizes in membrane lipid rafts, PAG This item specifically recognizes the transmembrane adaptor protein known as Protein Associated with Glycosphingolipid-enriched microdomains (PAG)
Purification methodN/A
Form/AppearancePurified (Purified IgG - liquid)
Concentration0 mg/ml, Ig concentration 1
Storage and shipping If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term
Tested applications:Western Blot (WB)
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°
Gene targetPAG
Short nameMOUSE Anti-HUMAN PAG Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative name sapiens PAG (Antibody to), MOUSE antibody to-H
Alternative techniqueantibodies
Identity 30043
Gene PAG1
Long gene name phosphoprotein membrane anchor with glycosphingolipid microdomains 1
Synonyms gene name phosphoprotein associated with glycosphingolipid microdomains 1
Synonyms PAG CBP
Synonyms name Csk-binding protein transmembrane adaptor protein PAG
Locus 8q21, 13
Discovery year 2005-04-25
GenBank acession AF240634
Entrez gene record 55824
Pubmed identfication 10790433
RefSeq identity NM_018440
Havana BLAST/BLAT OTTHUMG00000164592

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