MOUSE Anti-HUMAN SOCS-3 Antibody

MOUSE Anti-HUMAN SOCS-3 Antibody size: 100ug 393

Price 393

Size 100ug

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Also known as	SOCS-3
Other names	CIS-3, CIS-3, Cytokine-inducible SH2 protein 3, STAT-induced STAT inhibitor 3, STAT-induced STAT inhibitor 3, Suppressor of cytokine signaling 3, cytokine-induced SH2 protein 3, cytokine-inducible SH2 protein 3, suppressor of cytokine signaling 3, suppressor of cytokine signaling 3, suppressor of cytokine signaling 3
Category	Antibodies
Subcategory	Mnoclonal antibodies
Gene name	SOCS-3
Gene name synonims	N/A
Other gene names	ATOD4, CIS-3, CIS3, CIS3, Cish3, SOCS-3, SOCS-3, SOCS3, SSI-3, SSI-3, SSI3, SSI3, SOCS3
Clonality	Monoclonal
Immunoglobulin isotype	IgG2b
Clone	SO1
Host organism	Mouse (Mus musculus)
Species reactivity	Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens)
Specificity and cross-reactivity	Colitis, IL-10, Recent studies in mice, SOCS-3 expression has also been shown to affect IFN alpha sensitivity in tumour studies, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, Toll-like receptor (TLR) agonists and IFN gamma, _x000D_The expression of SOCS-3 is inducible by numerous factors, _x000D__x000D_SOCS-3 specifically acts as a negative feedback regulator for the STAT3 pathways, a 30kDa member of the suppressor of cytokine signaling family (SOCS) which negatively regulate Janus Kinase (JAK) and signal transducer and activators of transcription (STAT) signaling pathways, and Crohn's Disease, and that RBPJ-mediated Notch signaling, by directly binding to the Tyr-759 motif of the IL-6 signal-transducing receptor subunit gp130, have shown Notch signaling plays a critical role in the determination of M1 versus M2 macrophage polarization, including IL-6, making this protein the focus of research into inflammatory diseases, regulates this polarization through SOCS-3, such as Arthritis, thereby preventing the IL-6 activation of STAT3, SOCS-3 This item recognizes suppressor of cytokine signaling 3 (SOCS-3)
Purification method	N/A
Form/Appearance	Purified (Purified IgG - liquid)
Concentration	0 mg/ml, Ig concentration 1
Storage and shipping	Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term
Tested applications:	ELISA (EIA), Western Blot (WB)
Properties	C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°
Gene target	SOCS-3
Short name	MOUSE Anti-HUMAN SOCS-3 Antibody
Technique	antibodies against human proteins, antibodies for, Antibody
Alternative name	sapiens SOCS-3 (Antibody to), MOUSE antibody to-H
Alternative technique	antibodies
Identity	19391
Gene	SOCS3
Long gene name	suppressor of cytokine signaling 3
Synonyms	SSI-3 CIS3 SOCS-3 Cish3
Locus	17q25, 3
Discovery year	2002-11-13
GenBank acession	AB004904
Entrez gene record	9021
Pubmed identfication	9266833 9344848
Classification	Suppressors of cytokine signaling SH2 domain containing
Havana BLAST/BLAT	OTTHUMG00000177513
Locus Specific Databases	LRG_619

MOUSE Anti-HUMAN SOCS-3 Antibody

MOUSE Anti-HUMAN SOCS-3 Antibody size: 100ug 393

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