| Also known as | ERN1 / IRE1 |
| Other names | ER to nucleus signalling 1, ERN1, Endoplasmic reticulum-to-nucleus signaling 1, IRE1a, Inositol-requiring protein 1, Ire1-alpha, Serine/threonine-protein kinase/endoribonuclease IRE1, endoplasmic reticulum to nucleus signaling 1, endoplasmic reticulum-to-nucleus signaling 1, hIRE1p, inositol-requiring 1, inositol-requiring enzyme 1, inositol-requiring protein 1, ire1-alpha, serine/threonine-protein kinase/endoribonuclease IRE1, serine/threonine-protein kinase/endoribonuclease IRE1 |
| Category | Antibodies |
| Subcategory | Mnoclonal antibodies |
| Gene name | ERN1 |
| Gene name synonims | IRE1 |
| Other gene names | ERN1, IRE1, IRE1P, IRE1a, IRE1a, hIRE1p, hIRE1p, ERN1 |
| Clonality | Monoclonal |
| Immunoglobulin isotype | IgG1, k |
| Clone | 3D1 |
| Host organism | Mouse (Mus musculus) |
| Species reactivity | Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity | Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, Human IRE1 |
| Purification method | Protein A Purified |
| Form/Appearance | pH 7, 2, PBS |
| Concentration | 39 mg/ml |
| Storage and shipping | For long term storage aliquot and keep the antibody at -20 degrees Celsius, Freeze-thaw cycles should be avoided in order to retain the activity of the antibody, Store at +4 degrees Celsius for short term storage |
| Tested applications: | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC - Paraffin) |
| Properties | Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About | Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test | A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name | Mus musculus |
| Gene target | Monoclonal [ 3D1] (IgG1, k) ERN1 / IRE1 |
| Short name | Mouse Monoclonal [clone 3D1] (IgG1, k) ERN1 / IRE1 Antibody |
| Technique | Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype | IgG1 |
| Species | Humans, Mouses, Human |
| Alternative name | sapiens endoplasmic reticulum to nucleus signaling 1 / IRE1 (Antibody to), Mouse monoclonal [clonality 3D1] (IgG1, k) to H |
| Alternative technique | antibodies |
| Alternative to gene target | DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0006397 and mRNA processing and biological process this GO :0006468 and protein phosphorylation and biological process this GO :0006987 and activation of signaling protein activity involved in unfolded protein response and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0016772 and transferase activity, ERN1 and IDBG-641835 and ENSBTAG00000016799 and 524719, ERN1 and IDBG-64539 and ENSG00000178607 and 2081, Ern1 and IDBG-213476 and ENSMUSG00000020715 and 78943, endonucleolytic and biological process this GO :1900103 and positive regulation of endoplasmic reticulum unfolded protein response and biological process, hIRE1p and IRE1 and IRE1a and IRE1P, nuclei, this GO :0000287 and magnesium ion binding and molecular function this GO :0004519 and endonuclease activity and molecular function this GO :0004521 and endoribonuclease activity and molecular function this GO :0004540 and ribonuclease activity and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005637 and nuclear inner membrane and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005789 and endoplasmic reticulum membrane and cellular component this GO :0006351 and transcription, this GO :0000287: magnesium ion binding, this GO :0000287: magnesium ion binding and also this GO :0004519: endonuclease activity and also this GO :0004521: endoribonuclease activity and also this GO :0004540: ribonuclease activity and also this GO :0004672: protein kinase activity and also this GO :0004674: protein serine/threonine kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0016772: transferase activity, this GO :0004519: endonuclease activity, this GO :0004521: endoribonuclease activity, this GO :0004540: ribonuclease activity, this GO :0004672: protein kinase activity, this GO :0004674: protein serine/threonine kinase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0016772: transferase activity, this GO :0019899: enzyme binding, this GO :0042802: identical protein binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0019899: enzyme binding and also this GO :0042802: identical protein binding, transferring phosphorus-containing groups and molecular function this GO :0019899 and enzyme binding and molecular function this GO :0030176 and integral component of endoplasmic reticulum membrane and cellular component this GO :0030968 and endoplasmic reticulum unfolded protein response and biological process this GO :0042802 and identical protein binding and molecular function this GO :0044267 and cellular protein metabolic process and biological process this GO :0045087 and innate immune response and biological process this GO :0046777 and protein autophosphorylation and biological process this GO :0070055 and HAC1-type intron splice site recognition and cleavage and biological process this GO :0070059 and intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress and biological process this GO :0090305 and nucleic acid phosphodiester bond hydrolysis and biological process this GO :0090502 and RNA phosphodiester bond hydrolysis, endoplasmic reticulum to nucleus signaling 1 |
| Identity | 3449 |
| Gene | ERN1 |
| Long gene name | endoplasmic reticulum to nucleus signaling 1 |
| Synonyms gene name | ER to nucleus signalling 1 |
| Synonyms | IRE1 IRE1P |
| Synonyms name | inositol-requiring enzyme 1 Serine/threonine-protein kinase/endoribonuclease IRE1 |
| Locus | 17q23, 3 |
| Discovery year | 1998-08-06 |
| GenBank acession | AF059198 |
| Entrez gene record | 2081 |
| Pubmed identfication | 9637683 |
| RefSeq identity | NM_001433 |
| Havana BLAST/BLAT | OTTHUMG00000178879 |
Technique
Supplier
Species
Label
Iso Type
Host
Tissue