| Also known as | XRCC6 / Ku70 |
| Other names | 5'-dRP lyase Ku70, 5'-dRP lyase Ku70, 5'-deoxyribose-5-phosphate lyase Ku70, 5'-deoxyribose-5-phosphate lyase Ku70, 70 kDa subunit, 70 kDa subunit of Ku antigen, 70 kDa subunit of Ku antigen, 70kDa, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase II, ATP-dependent DNA helicase II 70 kDa subunit, ATP-dependent DNA helicase II 70 kDa subunit, CTC box binding factor 75 kDa subunit, CTC box-binding factor 75 kDa subunit, CTC box-binding factor 75 kDa subunit, CTC75, CTCBF, DNA repair protein XRCC6, DNA repair protein XRCC6, Ku autoantigen, Ku autoantigen p70 subunit, Ku70, Lupus Ku autoantigen protein p70, TLAA, Thyroid-lupus autoantigen, X-ray repair complementing defective repair in Chinese hamster cells 6, X-ray repair complementing defective repair in Chinese hamster cells 6, X-ray repair cross-complementing protein 6, X-ray repair cross-complementing protein 6, lupus Ku autoantigen protein p70, thyroid autoantigen 70kD (Ku antigen), thyroid autoantigen 70kDa (Ku antigen), thyroid-lupus autoantigen p70, X-ray repair cross-complementing protein 6 isoform 1 |
| Category | Antibodies |
| Subcategory | Mnoclonal antibodies |
| Gene name | XRCC6 |
| Gene name synonims | N/A |
| Other gene names | 5'-dRP lyase Ku70, CTC75, CTC75, CTCBF, CTCBF, G22P1, G22P1, KU70, Ku70, ML8, TLAA, TLAA, XRCC6, XRCC6 |
| Clonality | Monoclonal |
| Immunoglobulin isotype | IgG1, k |
| Clone | 4C2-1A6 |
| Host organism | Mouse (Mus musculus) |
| Species reactivity | Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity | Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, Human XRCC6 |
| Purification method | Protein A Purified |
| Form/Appearance | Sourced in Ascites, pH 7, 2, PBS |
| Concentration | 5 mg/ml |
| Storage and shipping | For long term storage aliquot and keep the antibody at -20 degrees Celsius, Freeze-thaw cycles should be avoided in order to retain the activity of the antibody, Store at +4 degrees Celsius for short term storage |
| Tested applications: | ELISA (EIA), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC - Paraffin) |
| Properties | Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About | Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test | A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name | Mus musculus |
| Gene target | Monoclonal [ 4C2-1A6] (IgG1, k) XRCC6 / Ku70 |
| Short name | Mouse Monoclonal [clone 4C2-1A6] (IgG1, k) XRCC6 / Ku70 Antibody |
| Technique | Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype | IgG1 |
| Species | Humans, Mouses, Human |
| Alternative name | sapiens X-ray repair complementing defective repair in Chinese hamster cells 6 / Ku70 (Antibody to), Mouse monoclonal [clonality 4C2-1A6] (IgG1, k) to H |
| Alternative technique | antibodies |
| Alternative to gene target | 5'-deoxyribose-5-phosphate lyase activity, CTC75 and CTCBF and G22P1 and KU70 and ML8 and TLAA, DNA-templated and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0007420 and brain development and biological process this GO :0008022 and protein C-terminus binding and molecular function this GO :0010212 and response to ionizing radiation and biological process this GO :0016020 and membrane and cellular component this GO :0016032 and viral process and biological process this GO :0032481 and positive regulation of type I interferon production and biological process this GO :0032508 and DNA duplex unwinding and biological process this GO :0033151 and V(D)J recombination and biological process this GO :0042162 and telomeric DNA binding and molecular function this GO :0043234 and protein complex and cellular component this GO :0043564 and Ku70:Ku80 complex and cellular component this GO :0044212 and transcription regulatory region DNA binding and molecular function this GO :0044822 and poly(A) RNA binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045892 and negative regulation of transcription, DNA-templated and biological process this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0050769 and positive regulation of neurogenesis and biological process this GO :0051575 and 5'-deoxyribose-5-phosphate lyase activity and molecular function this GO :0070419 and nonhomolo this GO us end joining complex and cellular component this GO :0071475 and cellular hyperosmotic salinity response and biological process this GO :0071481 and cellular response to X-ray and biological process this GO :0075713 and establishment of integrated proviral latency and biological process, XRCC6 and IDBG-641933 and ENSBTAG00000006103 and 510132, XRCC6 and IDBG-9323 and ENSG00000196419 and 2547, Xrcc6 and IDBG-165874 and ENSMUSG00000022471 and 14375, nuclei, this GO :0000723 and telomere maintenance and biological process this GO :0000783 and nuclear telomere cap complex and cellular component this GO :0003677 and DNA binding and molecular function this GO :0003684 and damaged DNA binding and molecular function this GO :0003690 and double-stranded DNA binding and molecular function this GO :0003691 and double-stranded telomeric DNA binding and molecular function this GO :0004003 and ATP-dependent DNA helicase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005667 and transcription factor complex and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006266 and DNA ligation and biological process this GO :0006281 and DNA repair and biological process this GO :0006302 and double-strand break repair and biological process this GO :0006303 and double-strand break repair via nonhomolo this GO us end joining and biological process this GO :0006351 and transcription, this GO :0003677: DNA binding, this GO :0003677: DNA binding and also this GO :0003684: damaged DNA binding and also this GO :0003690: double-stranded DNA binding and also this GO :0003691: double-stranded telomeric DNA binding and also this GO :0004003: ATP-dependent DNA helicase activity and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0008022: protein C-terminus binding and also this GO :0042162: telomeric DNA binding and also this GO :0044212: transcription regulatory region DNA binding and also this GO :0044822: poly(A) RNA binding and also this GO :0051575: 5'-deoxyribose-5-phosphate lyase activity, this GO :0003684: damaged DNA binding, this GO :0003690: double-stranded DNA binding, this GO :0003691: double-stranded telomeric DNA binding, this GO :0004003: ATP-dependent DNA helicase activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0008022: protein C-terminus binding, this GO :0042162: telomeric DNA binding, this GO :0044212: transcription regulatory region DNA binding, this GO :0044822: poly(A) RNA binding, this GO :0051575: 5'-deoxyribose-5-phosphate lyase activity, X-ray repair complementing defective repair in Chinese hamster cells 6 |
| Identity | 4055 |
| Gene | XRCC6 |
| Long gene name | X-ray repair cross complementing 6 |
| Synonyms gene | G22P1 |
| Synonyms gene name | thyroid autoantigen 70kD (Ku antigen) thyroid autoantigen 70kDa (Ku antigen) X-ray repair complementing defective repair in Chinese hamster cells 6 |
| Synonyms | D22S731 D22S671 KU70 ML8 |
| Synonyms name | 70kDa , Ku autoantigen |
| Locus | 22q13, 2 |
| Discovery year | 1988-05-11 |
| GenBank acession | J04607 |
| Entrez gene record | 2547 |
| Pubmed identfication | 9200330 9223317 |
| RefSeq identity | NM_001469 |
| Classification | DNA helicases |
| Havana BLAST/BLAT | OTTHUMG00000151190 |
Technique
Supplier
Species
Label
Iso Type
Host
Tissue