| Also known as | CASP1 / Caspase 1 |
| Other names | CASP1 nirs variant 1, Caspase-1, Caspase-1 subunit p10, ICE, IL-1 beta-converting enzyme, IL-1 beta-converting enzyme, IL-1BC, IL1B-convertase, Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, apoptosis-related cysteine peptidase, apoptosis-related cysteine peptidase (interleukin 1, beta, beta, caspase 1, caspase 1, caspase-1, convertase, convertase), interleukin 1, interleukin 1-B converting enzyme, p45Cleaved into the following 2 chains:Caspase-1 subunit p20, caspase-1 isoform beta |
| Category | Antibodies |
| Subcategory | Mnoclonal antibodies |
| Gene name | CASP1 |
| Gene name synonims | N/A |
| Other gene names | CASP-1, CASP1, ICE, ICE, IL-1 beta-converting enzyme, IL-1BC, IL1BC, IL1BC, IL1BCE, P45, CASP1 |
| Clonality | Monoclonal |
| Immunoglobulin isotype | IgG1 |
| Clone | 14F468 |
| Host organism | Mouse (Mus musculus) |
| Species reactivity | Bat (at least 90% immunogen sequence identity), Due to limited knowledge and inability for testing each and every species, Gorilla, Human (Homo sapiens) <, the reactivity of the antibody may extend to other species which are not listed hereby, /b>, Gibbon, Predicted Reactivity: <, Rat (Rattus norvegicus), b> |
| Specificity and cross-reactivity | It will cross-react with mouse and rat Caspase-1, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, based on NCBI BLAST, A synthetic peptide corresponding to amino acids 371-390 RKVRFSFEQPDGRAQMPTTE of human caspase-1 was used as immunogen |
| Purification method | Protein G Purified |
| Form/Appearance | 0, 0, 05% BSA, 05% sodium azide, PBS |
| Concentration | 5 mg/ml |
| Storage and shipping | Cycles of freezing and defrosting may denaturate the polypeptide chains of the antibodies and reduce their activity, For longer storage the antibody should be kept at -20 degrees Celsius, For short term storage keep the antibody at +4 degrees Celsius |
| Tested applications: | Western Blot (WB), Immunohistochemistry (IHC - Paraffin) |
| Properties | Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About | Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test | A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name | Mus musculus |
| Gene target | Monoclonal [ 14F468] (IgG1) CASP1 / Caspase 1 |
| Short name | Mouse Monoclonal [clone 14F468] (IgG1) CASP1 / Caspase 1 Antibody |
| Technique | Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype | IgG1 |
| Species | Humans, Mouses, Human |
| Alternative name | apoptosis-related cysteine peptidase / caspase 1 (Antibody to), sapiens caspase 1, Mouse monoclonal [clonality 14F468] (IgG1) to H |
| Alternative technique | antibodies |
| Alternative to gene target | CASP1 and IDBG-69618 and ENSG00000137752 and 834, Casp1 and IDBG-131590 and ENSMUSG00000025888 and 12362, Extracellular, ICE and IL1BC and P45, apoptosis-related cysteine peptidase, cysteine-type endopeptidase activator activity involved in apoptotic process, leucine rich repeat containing receptor signaling pathway and biological process this GO :0042981 and regulation of apoptotic process and biological process this GO :0043123 and positive regulation of I-kappaB kinase/NF-kappaB signaling and biological process this GO :0045087 and innate immune response and biological process this GO :0050715 and positive regulation of cytokine secretion and biological process this GO :0050717 and positive regulation of interleukin-1 alpha secretion and biological process this GO :0050718 and positive regulation of interleukin-1 beta secretion and biological process this GO :0050727 and regulation of inflammatory response and biological process this GO :0051882 and mitochondrial depolarization and biological process this GO :0060081 and membrane hyperpolarization and biological process this GO :0070269 and pyroptosis and biological process this GO :0071260 and cellular response to mechanical stimulus and biological process this GO :0071310 and cellular response to organic substance and biological process this GO :0072557 and IPAF inflammasome complex and cellular component this GO :0072558 and NLRP1 inflammasome complex and cellular component this GO :0072559 and NLRP3 inflammasome complex and cellular component this GO :0097169 and AIM2 inflammasome complex and cellular component this GO :0097194 and execution phase of apoptosis and biological process this GO :0097300 and programmed necrotic cell death and biological process, this GO :0001666 and response to hypoxia and biological process this GO :0004175 and endopeptidase activity and molecular function this GO :0004197 and cysteine-type endopeptidase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005622 and intracellular and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006508 and proteolysis and biological process this GO :0006915 and apoptotic process and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0008233 and peptidase activity and molecular function this GO :0008234 and cysteine-type peptidase activity and molecular function this GO :0008656 and cysteine-type endopeptidase activator activity involved in apoptotic process and molecular function this GO :0016485 and protein processing and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0032611 and interleukin-1 beta production and biological process this GO :0033198 and response to ATP and biological process this GO :0035872 and nucleotide-binding domain, this GO :0004175: endopeptidase activity, this GO :0004175: endopeptidase activity and also this GO :0004197: cysteine-type endopeptidase activity and also this GO :0005515: protein binding and also this GO :0008233: peptidase activity and also this GO :0008234: cysteine-type peptidase activity and also this GO :0008656: cysteine-type endopeptidase activator activity involved in apoptotic process, this GO :0004197: cysteine-type endopeptidase activity, this GO :0005515: protein binding, this GO :0008233: peptidase activity, this GO :0008234: cysteine-type peptidase activity, this GO :0008656: cysteine-type endopeptidase activator activity involved in apoptotic process, caspase 1 |
| Identity | 1499 |
| Gene | CASP1 |
| Long gene name | caspase 1 |
| Synonyms gene | IL1BC |
| Synonyms gene name | apoptosis-related cysteine peptidase , apoptosis-related cysteine peptidase (interleukin 1, apoptosis-related cysteine protease (interleukin 1, beta, beta, caspase 1, convertase) caspase 1, convertase) caspase 1 |
| Synonyms | ICE |
| Synonyms name | beta, caspase-1 interleukin 1, convertase |
| Locus | 11q22, 3 |
| Discovery year | 1992-05-07 |
| GenBank acession | U13697 |
| Entrez gene record | 834 |
| Pubmed identfication | 1373520 9250871 |
| RefSeq identity | NM_033292 |
| Classification | Caspase recruitment domain containing Caspases |
| Havana BLAST/BLAT | OTTHUMG00000048072 |
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