| Also known as | SERPINE1 / PAI-1 |
| Other names | Endothelial plasminogen activator inhibitor, Plasminogen activator inhibitor 1, Serpin E1, clade E (nexin, clade E (nexin, endothelial plasminogen activator inhibitor, member 1, member 1, plasminogen activator inhibitor 1, plasminogen activator inhibitor type 1), plasminogen activator inhibitor type 1), serine (or cysteine) proteinase inhibitor, serpin E1, serpin peptidase inhibitor, plasminogen activator inhibitor 1 |
| Category | Antibodies |
| Subcategory | Mnoclonal antibodies |
| Gene name | SERPINE1 |
| Gene name synonims | PAI-1 |
| Other gene names | PAI, PAI, PAI-1, PAI-1, PAI1, PAI1, PLANH1, PLANH1, SERPINE1, SERPINE1 |
| Clonality | Monoclonal |
| Immunoglobulin isotype | IgG1 |
| Clone | 1D5 |
| Host organism | Mouse (Mus musculus) |
| Species reactivity | Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity | Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, Human SERPINE1 / PAI-1 |
| Purification method | Purified |
| Form/Appearance | 0, 0, 05% protein stabilizer, 05% sodium azide, PBS |
| Concentration | 1 miligram per 1 mililiter |
| Storage and shipping | Cycles of freezing/defrosting can damage the peptide chains of the antibodies thus reducing the activity, Short term storage of the antibody can be done at +4 degrees Celsius, keep the antibody at -20 degrees Celsius, For long term storage |
| Tested applications: | ELISA (EIA), Flow Cytometry (FC/FACS), Western Blot (WB), Immunohistochemistry (IHC) |
| Properties | Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About | Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test | A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name | Mus musculus |
| Gene | SERPINE1 |
| Gene target | Monoclonal [ 1D5] (IgG1) SERPINE1 / PAI-1 |
| Short name | Mouse Monoclonal [clone 1D5] (IgG1) SERPINE1 / PAI-1 Antibody |
| Technique | Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype | IgG1 |
| Species | Humans, Mouses, Human |
| Alternative name | clade E (nexin, member 1 / PAI-1 (Antibody to), plasminogen activator inhibitor classification 1), sapiens serpin peptidase inhibitor, Mouse monoclonal [clonality 1D5] (IgG1) to H |
| Alternative technique | antibodies |
| Alternative to gene target | DNA-templated and biological process this GO :0006367 and transcription initiation from RNA polymerase II promoter and biological process this GO :0007179 and transforming growth factor beta receptor signaling pathway and biological process this GO :0007596 and blood coagulation and biological process this GO :0010467 and gene expression and biological process this GO :0010469 and regulation of receptor activity and biological process this GO :0010757 and negative regulation of plasminogen activation and biological process this GO :0010951 and negative regulation of endopeptidase activity and biological process this GO :0014912 and negative regulation of smooth muscle cell migration and biological process this GO :0030168 and platelet activation and biological process this GO :0030194 and positive regulation of blood coagulation and biological process this GO :0030195 and negative regulation of blood coagulation and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0030336 and negative regulation of cell migration and biological process this GO :0031012 and extracellular matrix and cellular component this GO :0031093 and platelet alpha granule lumen and cellular component this GO :0032757 and positive regulation of interleukin-8 production and biological process this GO :0033629 and negative regulation of cell adhesion mediated by integrin and biological process this GO :0035491 and positive regulation of leukotriene production involved in inflammatory response and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042730 and fibrinolysis and biological process this GO :0045087 and innate immune response and biological process this GO :0045765 and regulation of angiogenesis and biological process this GO :0045766 and positive regulation of angiogenesis and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048260 and positive regulation of receptor-mediated endocytosis and biological process this GO :0050729 and positive regulation of inflammatory response and biological process this GO :0050829 and defense response to Gram-negative bacterium and biological process this GO :0051918 and negative regulation of fibrinolysis and biological process this GO :0061044 and negative regulation of vascular wound healing and biological process this GO :0061045 and negative regulation of wound healing and biological process this GO :0071222 and cellular response to lipopolysaccharide and biological process this GO :0090026 and positive regulation of monocyte chemotaxis and biological process this GO :1902042 and negative regulation of extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :2000098 and negative regulation of smooth muscle cell-matrix adhesion and biological process this GO :2000352 and negative regulation of endothelial cell apoptotic process and biological process, Extracellular, PAI and PAI-1 and PAI1 and PLANH1, SERPINE1 and IDBG-32959 and ENSG00000106366 and 5054, SERPINE1 and IDBG-640415 and ENSBTAG00000014465 and 281375, Serpine1 and IDBG-204786 and ENSMUSG00000037411 and 18787, clade E (nexin, member 1, plasminogen activator inhibitor type 1), protein binding, this GO :0001300 and chronological cell aging and biological process this GO :0001525 and angiogenesis and biological process this GO :0002020 and protease binding and molecular function this GO :0002576 and platelet degranulation and biological process this GO :0004867 and serine-type endopeptidase inhibitor activity and molecular function this GO :0005102 and receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006351 and transcription, this GO :0002020: protease binding, this GO :0002020: protease binding and also this GO :0004867: serine-type endopeptidase inhibitor activity and also this GO :0005102: receptor binding and also this GO :0005515: protein binding, this GO :0004867: serine-type endopeptidase inhibitor activity, this GO :0005102: receptor binding, this GO :0005515: protein binding, serpin peptidase inhibitor |
| Identity | 8583 |
| Long gene name | serpin family E member 1 |
| Synonyms gene | PLANH1 PAI1 |
| Synonyms gene name | clade E (nexin, clade E (nexin, member 1 , member 1 serpin peptidase inhibitor, plasminogen activator inhibitor type 1), plasminogen activator inhibitor type 1), serine (or cysteine) proteinase inhibitor |
| Synonyms | PAI |
| Synonyms name | plasminogen activator inhibitor, type I |
| Locus | 7q22, 1 |
| Discovery year | 1986-01-01 |
| GenBank acession | M16006 |
| Entrez gene record | 5054 |
| Pubmed identfication | 3097076 2891140 24172014 |
| RefSeq identity | NM_000602 |
| Classification | Serpin peptidase inhibitors |
| Havana BLAST/BLAT | OTTHUMG00000157107 |
| Locus Specific Databases | LRG_597 |
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