| Also known as | TRF1 / TERF1 |
| Other names | NIMA-interacting protein 2, NIMA-interacting protein 2, TTAGGG repeat-binding factor 1, TTAGGG repeat-binding factor 1, Telomeric protein Pin2/TRF1, Telomeric repeat-binding factor 1, telomeric protein Pin2/TRF1, telomeric repeat binding factor (NIMA-interacting) 1, telomeric repeat-binding factor 1, telomeric repeat-binding factor 1 isoform 1 |
| Category | Antibodies |
| Subcategory | Mnoclonal antibodies |
| Gene name | TRF1 |
| Gene name synonims | TERF1 |
| Other gene names | PIN2, PIN2, TERF1, TRBF1, TRBF1, TRF, TRF, TRF1, TRF1, hTRF1-AS, t-TRF1, TERF1 |
| Clonality | Monoclonal |
| Immunoglobulin isotype | IgG1 |
| Clone | BED5 |
| Host organism | Mouse (Mus musculus) |
| Species reactivity | Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity | Additionally in conjunction with POT1 and TTAGGG repeat binding factor 1 (TRF2), Along with tankyrase-1, If the telomere is long enough, POT1, Protection of telomeres-1 (POT1) is a single-stranded telomeric DNA-binding protein which controls the elongation of telomeres by telomerase, Reported to work in Western blotting applications, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, TIN2, TIN2, TPP1, TRF1 along with TRF2, TRF1 binds the double-stranded TTAGGG repeat of telomeres and regulates telomere length, TRF1 mediates the loading of POT1 onto single stranded DNA, TRF1 recruits factors to the telomere, This particular antibody might cross react with speacies outside of the listed ones, and PINX1, and Rap1 form the shelterin complex which distinguishes telomeres from sites of DNA damage, conveying information about telomere length to the telomere terminus, inducing the formation of the protective t-loop, telomerase is inhibited, where telomerase is regulated, Recognizes TTAGGG repeat binding factor 1 (TRF1) a ubiquitously expressed 60kD protein |
| Purification method | Affinity Purified |
| Form/Appearance | 0, Sourced in TCS, pH 7, 09% sodium azide, 4, PBS |
| Concentration | 1 miligram per 1 mililiter |
| Storage and shipping | For long term storage aliquot and keep the antibody at -20 degrees Celsius, Freeze-thaw cycles should be avoided in order to retain the activity of the antibody, Store at +4 degrees Celsius for short term storage |
| Tested applications: | ELISA (EIA), IHC - Frozen), Immunohistochemistry (IHC - Paraffin |
| Properties | Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About | Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test | A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name | Mus musculus |
| Gene target | Monoclonal [ BED5] (IgG1) TRF1 / TERF1 |
| Short name | Mouse Monoclonal [clone BED5] (IgG1) TRF1 / TERF1 Antibody |
| Technique | Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype | IgG1 |
| Species | Humans, Mouses, Human |
| Alternative name | sapiens TRF1 / telomeric repeat binding factor (NIMA-interacting) 1 (Antibody to), Mouse monoclonal [clonality BED5] (IgG1) to H |
| Alternative technique | antibodies |
| Alternative to gene target | BT, DNA binding, TERF1 and IDBG-25349 and ENSG00000147601 and 7013, Terf1 and IDBG-134893 and ENSMUSG00000025925 and 21749, bending, bending and also this GO :0042162: telomeric DNA binding and also this GO :0042803: protein homodimerization activity and also this GO :0046982: protein heterodimerization activity, bending and molecular function this GO :0010834 and telomere maintenance via telomere shortening and biological process this GO :0031116 and positive regulation of microtubule polymerization and biological process this GO :0032211 and negative regulation of telomere maintenance via telomerase and biological process this GO :0032214 and negative regulation of telomere maintenance via semi-conservative replication and biological process this GO :0042162 and telomeric DNA binding and molecular function this GO :0042493 and response to drug and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0045840 and positive regulation of mitosis and biological process this GO :0045931 and positive regulation of mitotic cell cycle and biological process this GO :0046982 and protein heterodimerization activity and molecular function this GO :0051260 and protein homooli this GO merization and biological process this GO :0051974 and negative regulation of telomerase activity and biological process, hTRF1-AS and PIN2 and t-TRF1 and TRBF1 and TRF and TRF1, nuclei, telomeric region and cellular component this GO :0000783 and nuclear telomere cap complex and cellular component this GO :0000784 and nuclear chromosome, telomeric region and cellular component this GO :0001309 and age-dependent telomere shortening and biological process this GO :0003677 and DNA binding and molecular function this GO :0003682 and chromatin binding and molecular function this GO :0003691 and double-stranded telomeric DNA binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005819 and spindle and cellular component this GO :0007004 and telomere maintenance via telomerase and biological process this GO :0007067 and mitotic nuclear division and biological process this GO :0007094 and mitotic spindle assembly checkpoint and biological process this GO :0008017 and microtubule binding and molecular function this GO :0008156 and negative regulation of DNA replication and biological process this GO :0008301 and DNA binding, this GO :0000086 and G2/M transition of mitotic cell cycle and biological process this GO :0000723 and telomere maintenance and biological process this GO :0000781 and chromosome, this GO :0003677: DNA binding, this GO :0003677: DNA binding and also this GO :0003682: chromatin binding and also this GO :0003691: double-stranded telomeric DNA binding and also this GO :0005515: protein binding and also this GO :0008017: microtubule binding and also this GO :0008301: DNA binding, this GO :0003682: chromatin binding, this GO :0003691: double-stranded telomeric DNA binding, this GO :0005515: protein binding, this GO :0008017: microtubule binding, this GO :0008301: DNA binding, this GO :0042162: telomeric DNA binding, this GO :0042803: protein homodimerization activity, this GO :0046982: protein heterodimerization activity, 23286 and IDBG-644763 and ENSBTAG00000032982 and 519474, telomeric repeat binding factor (NIMA-interacting) 1 |
| Identity | 11728 |
| Gene | TERF1 |
| Long gene name | telomeric repeat binding factor 1 |
| Synonyms gene | TRBF1 |
| Synonyms gene name | telomeric repeat binding factor (NIMA-interacting) 1 |
| Synonyms | PIN2 TRF1 TRF |
| Locus | 8q21, 11 |
| Discovery year | 1997-11-20 |
| GenBank acession | U74382 |
| Entrez gene record | 7013 |
| Pubmed identfication | 9391075 |
| RefSeq identity | NM_017489 |
| Classification | Shelterin complex Myb/SANT domain containing |
| Havana BLAST/BLAT | OTTHUMG00000164522 |
Technique
Supplier
Species
Label
Iso Type
Host
Tissue