| Also known as | TOPORS |
| Other names | E3 ubiquitin protein ligase, E3 ubiquitin-protein ligase Topors, E3 ubiquitin-protein ligase Topors, SUMO1-protein E3 ligase Topors, SUMO1-protein E3 ligase Topors, Topoisomerase I-binding RING finger protein, Topoisomerase I-binding arginine/serine-rich protein, Tumor suppressor p53-binding protein 3, arginine/serine-rich, p53-binding protein 3, p53BP3, topoisomerase I binding, topoisomerase I-binding RING finger protein, tumor suppressor p53-binding protein 3, E3 ubiquitin-protein ligase Topors isoform 1 |
| Category | Antibodies |
| Subcategory | Mnoclonal antibodies |
| Gene name | TOPORS |
| Gene name synonims | N/A |
| Other gene names | LUN, LUN, P53BP3, RP31, TOPORS, TP53BPL, TP53BPL, p53-binding protein 3, p53BP3, TOPORS |
| Clonality | Monoclonal |
| Immunoglobulin isotype | IgG2a, k |
| Clone | 5G11 |
| Host organism | Mouse (Mus musculus) |
| Species reactivity | Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity | Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, N/A |
| Purification method | Protein A Purified |
| Form/Appearance | pH 7, 2, PBS |
| Concentration | 4 mg/ml |
| Storage and shipping | We strongly recommend to avoid freeze/thaw cycles in order to keep the activity of the antibody maximally unchanged, the antibody should be kept at -20 degrees Celsius, For optimal long term storage |
| Tested applications: | ELISA (EIA), Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC - Paraffin) |
| Properties | Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About | Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test | A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name | Mus musculus |
| Gene target | Monoclonal [ 5G11] (IgG2a, k) TOPORS |
| Short name | Mouse Monoclonal [clone 5G11] (IgG2a, k) TOPORS Antibody |
| Technique | Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype | IgG2a |
| Species | Humans, Mouses, Human |
| Alternative name | E3 ubiquitin protein ligase (Antibody to), arginine/serine-rich, sapiens topoisomerase I binding, Mouse monoclonal [clonality 5G11] (IgG2a, k) to H |
| Alternative technique | antibodies |
| Alternative to gene target | DNA-templated and biological process this GO :0006511 and ubiquitin-dependent protein catabolic process and biological process this GO :0006513 and protein monoubiquitination and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0008270 and zinc ion binding and molecular function this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0010842 and retina layer formation and biological process this GO :0016605 and PML body and cellular component this GO :0016607 and nuclear speck and cellular component this GO :0016925 and protein sumoylation and biological process this GO :0019789 and SUMO ligase activity and molecular function this GO :0030496 and midbody and cellular component this GO :0032391 and photoreceptor connecting cilium and cellular component this GO :0034504 and protein localization to nucleus and biological process this GO :0035845 and photoreceptor cell outer segment organization and biological process this GO :0036064 and ciliary basal body and cellular component this GO :0042127 and regulation of cell proliferation and biological process this GO :0042771 and intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043161 and proteasome-mediated ubiquitin-dependent protein catabolic process and biological process this GO :0044547 and DNA topoisomerase binding and molecular function this GO :0045893 and positive regulation of transcription, DNA-templated and biological process this GO :0046548 and retinal rod cell development and biological process this GO :0046549 and retinal cone cell development and biological process this GO :0046872 and metal ion binding and molecular function this GO :0051443 and positive regulation of ubiquitin-protein transferase activity and biological process this GO :0051457 and maintenance of protein location in nucleus and biological process this GO :0070936 and protein K48-linked ubiquitination and biological process, E3 ubiquitin protein ligase, LUN and P53BP3 and RP31 and TP53BPL, TOPORS and IDBG-55971 and ENSG00000197579 and 10210, TOPORS and IDBG-629770 and ENSBTAG00000005905 and 523321, Topors and IDBG-136139 and ENSMUSG00000036822 and 106021, arginine/serine-rich, metal ion binding, nuclei, this GO :0000151 and ubiquitin ligase complex and cellular component this GO :0000922 and spindle pole and cellular component this GO :0000930 and gamma-tubulin complex and cellular component this GO :0003677 and DNA binding and molecular function this GO :0003823 and antigen binding and molecular function this GO :0004842 and ubiquitin-protein transferase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005814 and centriole and cellular component this GO :0005868 and cytoplasmic dynein complex and cellular component this GO :0006351 and transcription, this GO :0003677: DNA binding, this GO :0003677: DNA binding and also this GO :0003823: antigen binding and also this GO :0004842: ubiquitin-protein transferase activity and also this GO :0005515: protein binding and also this GO :0008270: zinc ion binding and also this GO :0019789: SUMO ligase activity and also this GO :0044547: DNA topoisomerase binding and also this GO :0046872: metal ion binding, this GO :0003823: antigen binding, this GO :0004842: ubiquitin-protein transferase activity, this GO :0005515: protein binding, this GO :0008270: zinc ion binding, this GO :0019789: SUMO ligase activity, this GO :0044547: DNA topoisomerase binding, this GO :0046872: metal ion binding, topoisomerase I binding |
| Identity | 21653 |
| Gene | TOPORS |
| Long gene name | TOP1 binding arginine/serine rich protein |
| Synonyms gene | RP31 |
| Synonyms gene name | E3 ubiquitin protein ligase , arginine/serine-rich, retinitis pigmentosa 31 (autosomal dominant) topoisomerase I binding |
| Synonyms | TP53BPL LUN |
| Locus | 9p21, 1 |
| Discovery year | 2003-07-07 |
| GenBank acession | AF098300 |
| Entrez gene record | 10210 |
| Pubmed identfication | 10352183 12083797 17924349 |
| RefSeq identity | NM_005802 |
| Classification | Ring finger proteins |
| Havana BLAST/BLAT | OTTHUMG00000019743 |
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