| Also known as | MAPK8 / JNK1 / JNK |
| Other names | JNK-46, JUN N-terminal kinase, MAP kinase 8, Mitogen-activated protein kinase 8, SAPK1c, Stress-activated protein kinase 1c, Stress-activated protein kinase JNK1, c-Jun N-terminal kinase 1, c-Jun N-terminal kinase 1, mitogen-activated protein kinase 8, mitogen-activated protein kinase 8, mitogen-activated protein kinase 8 isoform JNK1 alpha1, mitogen-activated protein kinase 8 isoform JNK1 beta2, stress-activated protein kinase 1, stress-activated protein kinase 1c, mitogen-activated protein kinase 8 isoform alpha2 |
| Category | Antibodies |
| Subcategory | Mnoclonal antibodies |
| Gene name | MAPK8 |
| Gene name synonims | JNK, JNK1 |
| Other gene names | JNK, JNK-46, JNK1, JNK1, JNK1A2, JNK21B1/2, MAP kinase 8, MAPK 8, MAPK8, PRKM8, PRKM8, SAPK1, SAPK1, SAPK1C, SAPK1c, SAPK1c, MAPK8 |
| Clonality | Monoclonal |
| Immunoglobulin isotype | IgG2b, k |
| Clone | 4H5 |
| Host organism | Mouse (Mus musculus) |
| Species reactivity | Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity | Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, Human MAPK8 / JNK1 |
| Purification method | Protein A Purified |
| Form/Appearance | pH 7, 2, PBS |
| Concentration | N/A |
| Storage and shipping | For long term storage aliquot and keep the antibody at -20 degrees Celsius, Freeze-thaw cycles should be avoided in order to retain the activity of the antibody, Store at +4 degrees Celsius for short term storage |
| Tested applications: | ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB), Immunohistochemistry (IHC - Paraffin) |
| Properties | Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp |
| About | Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones |
| Test | A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or |
| Latin name | Mus musculus |
| Gene target | Monoclonal [ 4H5] (IgG2b, k) MAPK8 / JNK1 / JNK |
| Short name | Mouse Monoclonal [clone 4H5] (IgG2b, k) MAPK8 / JNK1 / JNK Antibody |
| Technique | Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody |
| Isotype | IgG2b |
| Species | Humans, Mouses, Human |
| Alternative name | sapiens mitogen-activated protein kinase 8 / JNK1 / JNK (Antibody to), Mouse monoclonal [clonality 4H5] (IgG2b, k) to H |
| Alternative technique | antibodies |
| Alternative to gene target | JNK and JNK-46 and JNK1 and JNK1A2 and JNK21B1/2 and PRKM8 and SAPK1 and SAPK1c, MAPK8 and IDBG-631635 and ENSBTAG00000007876 and 539941, MAPK8 and IDBG-73479 and ENSG00000107643 and 5599, Mapk8 and IDBG-148417 and ENSMUSG00000021936 and 26419, alcohol group as acceptor, alcohol group as acceptor and also this GO :0035033: histone deacetylase regulator activity and also this GO :0042826: histone deacetylase binding, alcohol group as acceptor and molecular function this GO :0018105 and peptidyl-serine phosphorylation and biological process this GO :0018107 and peptidyl-threonine phosphorylation and biological process this GO :0031063 and regulation of histone deacetylation and biological process this GO :0032091 and negative regulation of protein binding and biological process this GO :0032880 and regulation of protein localization and biological process this GO :0034134 and toll-like receptor 2 signaling pathway and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034146 and toll-like receptor 5 signaling pathway and biological process this GO :0034162 and toll-like receptor 9 signaling pathway and biological process this GO :0034166 and toll-like receptor 10 signaling pathway and biological process this GO :0035033 and histone deacetylase regulator activity and molecular function this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0038123 and toll-like receptor TLR1:TLR2 signaling pathway and biological process this GO :0038124 and toll-like receptor TLR6:TLR2 signaling pathway and biological process this GO :0042826 and histone deacetylase binding and molecular function this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0046686 and response to cadmium ion and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0051090 and regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0051403 and stress-activated MAPK cascade and biological process this GO :0070301 and cellular response to hydrogen peroxide and biological process this GO :0071222 and cellular response to lipopolysaccharide and biological process this GO :0071260 and cellular response to mechanical stimulus and biological process this GO :0071732 and cellular response to nitric oxide and biological process this GO :0090045 and positive regulation of deacetylase activity and biological process this GO :0097190 and apoptotic signaling pathway and biological process this GO :0097193 and intrinsic apoptotic signaling pathway and biological process this GO :0097300 and programmed necrotic cell death and biological process this GO :1900740 and positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway and biological process this GO :2000017 and positive regulation of determination of dorsal identity and biological process this GO :2001235 and positive regulation of apoptotic signaling pathway and biological process, nuclei, this GO :0000165 and MAPK cascade and biological process this GO :0001503 and ossification and biological process this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002755 and MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0003824 and catalytic activity and molecular function this GO :0004672 and protein kinase activity and molecular function this GO :0004674 and protein serine/threonine kinase activity and molecular function this GO :0004705 and JUN kinase activity and molecular function this GO :0004707 and MAP kinase activity and molecular function this GO :0004713 and protein tyrosine kinase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005829 and cytosol and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006915 and apoptotic process and biological process this GO :0006950 and response to stress and biological process this GO :0007254 and JNK cascade and biological process this GO :0007258 and JUN phosphorylation and biological process this GO :0009103 and lipopolysaccharide biosynthetic process and biological process this GO :0009411 and response to UV and biological process this GO :0010468 and regulation of gene expression and biological process this GO :0010628 and positive regulation of gene expression and biological process this GO :0016020 and membrane and cellular component this GO :0016301 and kinase activity and molecular function this GO :0016772 and transferase activity, this GO :0003824: catalytic activity, this GO :0003824: catalytic activity and also this GO :0004672: protein kinase activity and also this GO :0004674: protein serine/threonine kinase activity and also this GO :0004705: JUN kinase activity and also this GO :0004707: MAP kinase activity and also this GO :0004713: protein tyrosine kinase activity and also this GO :0005515: protein binding and also this GO :0005524: ATP binding and also this GO :0016301: kinase activity and also this GO :0016772: transferase activity, this GO :0004672: protein kinase activity, this GO :0004674: protein serine/threonine kinase activity, this GO :0004705: JUN kinase activity, this GO :0004707: MAP kinase activity, this GO :0004713: protein tyrosine kinase activity, this GO :0005515: protein binding, this GO :0005524: ATP binding, this GO :0016301: kinase activity, this GO :0016772: transferase activity, this GO :0016773: phosphotransferase activity, this GO :0035033: histone deacetylase regulator activity, this GO :0042826: histone deacetylase binding, transferase activity, transferring phosphorus-containing groups, transferring phosphorus-containing groups and also this GO :0016773: phosphotransferase activity, transferring phosphorus-containing groups and molecular function this GO :0016773 and phosphotransferase activity, mitogen-activated protein kinase 8 |
| Identity | 6881 |
| Gene | MAPK8 |
| Long gene name | mitogen-activated protein kinase 8 |
| Synonyms gene | PRKM8 |
| Synonyms | JNK JNK1 SAPK1 |
| Synonyms name | JUN N-terminal kinase |
| Locus | 10q11, 22 |
| Discovery year | 1998-04-28 |
| GenBank acession | L26318 |
| Entrez gene record | 5599 |
| Pubmed identfication | 8137421 8654373 |
| Classification | Mitogen-activated protein kinases |
| Havana BLAST/BLAT | OTTHUMG00000018172 |
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