Mouse Monoclonal [clone SO1] (IgG2b) to Human SOCS3 Antibody

Mouse Monoclonal [clone SO1] (IgG2b) to Human SOCS3 Antibody size: 50ug 597

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Also known as	SOCS3
Other names	CIS-3, Cytokine-inducible SH2 protein 3, SSI-3, STAT-induced STAT inhibitor 3, STAT-induced STAT inhibitor 3, Suppressor of cytokine signaling 3, cytokine-inducible SH2 protein 3, suppressor of cytokine signaling 3, suppressor of cytokine signaling 3, suppressor of cytokine signaling 3
Category	Antibodies
Subcategory	Mnoclonal antibodies
Gene name	SOCS3
Gene name synonims	N/A
Other gene names	ATOD4, CIS-3, CIS3, CIS3, Cish3, SOCS-3, SOCS-3, SOCS3, SSI-3, SSI-3, SSI3, SSI3, SOCS3
Clonality	Monoclonal
Immunoglobulin isotype	IgG2b
Clone	SO1
Host organism	Mouse (Mus musculus)
Species reactivity	Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens)
Specificity and cross-reactivity	Colitis, IL-10, SOCS3 expression has also been shown to affect IFN alpha sensitivity in tumor studies, SOCS3 specifically acts as a negative feedback regulator for the STAT3 pathways, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The expression of SOCS3 is inducible by numerous factors, This particular antibody might cross react with speacies outside of the listed ones, Toll-like receptor (TLR) agonists and IFN gamma, a 30kD member of the suppressor of cytokine signaling family (SOCS) which negatively regulate Janus Kinase (JAK) and signal transducer and activators of transcription (STAT) signaling pathways, and Crohn's Disease, by directly binding to the Tyr-759 motif of the IL-6 signal-transducing receptor subunit gp130, including IL-6, making this protein the focus of research into inflammatory diseases, such as Arthritis, thereby preventing the IL-6 activation of STAT3, Recognizes suppressor of cytokine signaling 3 (SOCS3)
Purification method	Protein A Purified
Form/Appearance	0, Sourced in TCS, pH 7, 09% sodium azide, 4, PBS
Concentration	1 miligram per 1 mililiter
Storage and shipping	Cycles of freezing and defrosting may denaturate the polypeptide chains of the antibodies and reduce their activity, For longer storage the antibody should be kept at -20 degrees Celsius, For short term storage keep the antibody at +4 degrees Celsius
Tested applications:	ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC - Paraffin)
Properties	Depending on the epitopes used human ELISA kits can be cross reactive to many other species, Human proteins, Mainly analyzed are human serum, Modern , cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies, human cell culture supernatants and biological samples, plasma, primarily , saliva, urine, , (Homo sapiens, C, C for long term storage and for short term at + 5°, Homo sapiens sapiens), If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24°, humans , ssp
About	Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Test	A/J, BALB/c, Mouse are mature after 40 days for females and 55 days for males, SCID while the CD-1 is outbred as strain, The female mice are pregnant only 20 days and can give birth to 10 litters of 6-8 mice a year, Transgenic, congenic and inbread strains are known for C57BL/6, knock-out, Mouse , mice from the Mus musculus species are used for production of mouse monoclonal antibodies or mabs and as research model for humans in your lab, or
Latin name	Mus musculus
Gene target	Monoclonal [ SO1] (IgG2b) SOCS3
Short name	Mouse Monoclonal [clone SO1] (IgG2b) SOCS3 Antibody
Technique	Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, mouses, Antibody
Isotype	IgG2b
Species	Humans, Mouses, Human
Alternative name	sapiens suppressor on cytokine signaling 3 (Antibody to), Mouse monoclonal [clonality SO1] (IgG2b) to H
Alternative technique	antibodies
Alternative to gene target	ATOD4 and CIS3 and Cish3 and SOCS-3 and SSI-3 and SSI3, Cytoplasm, SOCS3 and IDBG-647946 and ENSBTAG00000008441 and 282081, SOCS3 and IDBG-70676 and ENSG00000184557 and 9021, Socs3 and IDBG-214604 and ENSMUSG00000053113 and 12702, protein binding, this GO :0001932 and regulation of protein phosphorylation and biological process this GO :0004860 and protein kinase inhibitor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005829 and cytosol and cellular component this GO :0006469 and negative regulation of protein kinase activity and biological process this GO :0007259 and JAK-STAT cascade and biological process this GO :0009968 and negative regulation of signal transduction and biological process this GO :0016567 and protein ubiquitination and biological process this GO :0019221 and cytokine-mediated signaling pathway and biological process this GO :0035556 and intracellular signal transduction and biological process this GO :0040008 and regulation of growth and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0045087 and innate immune response and biological process this GO :0045595 and regulation of cell differentiation and biological process this GO :0045597 and positive regulation of cell differentiation and biological process this GO :0046627 and negative regulation of insulin receptor signaling pathway and biological process this GO :0060333 and interferon-gamma-mediated signaling pathway and biological process this GO :0060334 and regulation of interferon-gamma-mediated signaling pathway and biological process this GO :0060337 and type I interferon signaling pathway and biological process this GO :0060338 and regulation of type I interferon-mediated signaling pathway and biological process this GO :0060397 and JAK-STAT cascade involved in growth hormone signaling pathway and biological process this GO :0060670 and branching involved in labyrinthine layer morphogenesis and biological process this GO :0060674 and placenta blood vessel development and biological process this GO :0060707 and trophoblast giant cell differentiation and biological process this GO :0060708 and spongiotrophoblast differentiation and biological process, this GO :0004860: protein kinase inhibitor activity, this GO :0004860: protein kinase inhibitor activity and also this GO :0005515: protein binding, this GO :0005515: protein binding, suppressor of cytokine signaling 3
Identity	19391
Gene	SOCS3
Long gene name	suppressor of cytokine signaling 3
Synonyms	SSI-3 CIS3 SOCS-3 Cish3
Locus	17q25, 3
Discovery year	2002-11-13
GenBank acession	AB004904
Entrez gene record	9021
Pubmed identfication	9266833 9344848
Classification	Suppressors of cytokine signaling SH2 domain containing
Havana BLAST/BLAT	OTTHUMG00000177513
Locus Specific Databases	LRG_619

Mouse Monoclonal [clone SO1] (IgG2b) to Human SOCS3 Antibody

Mouse Monoclonal [clone SO1] (IgG2b) to Human SOCS3 Antibody size: 50ug 597

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