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MRGPRX1/3/4 Antibody

MRGPRX1/3/4 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameMRGPRX1/3/4 Primary Polyclonal Antibody
Also known asMRGPRX1/3/4 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenMRGPRX1/3/4
Specificity This may preferentially target MRGPRX1 over 3 and 4 due to slightly higher sequence similarity, This is a highly specific antibody against MRGPRX1/3/4
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range1-35/322
Subcellular locationExtracellular
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MRGX1
Gene ID number 117195, 117196, 259249
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells, G Alpha q proteins are involved in the calcium-signaling pathway downstream of the MRGX receptors, G(alpha)q proteins are involved in the calcium-signaling pathway, MRGX receptors are unique in that they are expressed in a subset of small dorsal root and trigeminal sensory neurons, MRGX1 and MRGX2 receptors stimulate both G Alpha q- and G Alpha i -regulated pathways, May regulate nociceptor function and/or development, Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22), Probably involved in the function of nociceptive neurons, including the sensation or modulation of pain, while MRGX3 and MRGX4 receptors mainly activate G Alpha q-regulated pathways, There are four members (MRGX1-4) in the human MRGX familly
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names G protein coupled receptor MRGX1, G protein coupled receptor SNSR3, GPCR, MAS related GPR member X1, MAS related gene MRGX1, MRGPRX1, MRGPRX3, MRGPRX4, MRGX1, MRGX1_HUMAN, MRGX3, MRGX4, Mas related G protein coupled receptor member X1, SNSR1, SNSR2, SNSR3, SNSR4, SNSR5, SNSR6, Sensory neuron specic G protein coupled receptor 3/4, Seven transmembrane helix receptor, MRGPRC
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetMRGPRX1/3/4
Short nameMRGPRX1/3/4 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative name member X1/3/4 (Antibody to), MAS-related GPR
Alternative techniqueantibodies
Alternative to gene target G-protein coupled receptor activity, MRGPRX1 and IDBG-35377 and ENSG00000170255 and 259249, Plasma membranes, member X1, this GO :0004930 and G-protein coupled receptor activity and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0006953 and acute-phase response and biological process this GO :0007186 and G-protein coupled receptor signaling pathway and biological process this GO :0016021 and integral component of membrane and cellular component, this GO :0004930: G-protein coupled receptor activity, this GO :0004930: G-protein coupled receptor activity, MAS-related GPR
Identity 17962
Gene MRGPRX1
Long gene name MAS related GPR family member X1
Synonyms gene name MAS-related GPR, member X1
Synonyms MRGX1
Locus 11p15, 1
Discovery year 2005-05-09
Entrez gene record 259249
Pubmed identfication 11551509
RefSeq identity NM_147199
Classification Class A orphans , G protein-coupled receptors
Havana BLAST/BLAT OTTHUMG00000162655

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