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MTM1 Antibody

MTM1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameMTM1 Primary Polyclonal Antibody
Also known asMTM1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenMTM1
SpecificityThis is a highly specific antibody against MTM1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MTM1/Myotubularin
Gene ID number4534
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Human MTM1, Myotubularin is primarily a lipid phosphatase that acts on phosphatidylinositol 3-monophosphate and is involved in the regulation of the phosphatidylinositol 3-kinase (PI3-kinase) pathway and membrane trafficking, The gene for MTM1 is localized to a 300 kb critical region on human Xq128 between IDS and GRBRA3, The gene responsible for myotubular myopathy MTM1 encodes a dual specificity phosphatase, The largely related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-Tooth neuropathy, Thus, Wild-type myotubularin can directly dephosphorylate PI3P and PI4P in vitro, a 603 amino-acid protein, in most cases, is mutated in myotubular myopathy, it decreases PI3P levels by down-regulating PI3K activity and by facilitating the degradation of PI3P, leads to early postnatal death, named myotubularin, which is highly conserved through evolution, X-linked recessive myotubular myopathy is a congenital muscular disease characterized by severe hypotonia and generalized muscle weakness that
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names CNM, KIAA4176, MTM1_HUMAN, MTMX, Mtm, Mtm1, Myotubular myopathy 1, Myotubularin, XLMTM, mKIAA4176, CG2
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetMTM1
Short nameMTM1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameMTM1 (Antibody to)
Alternative techniqueantibodies
Identity 7448
Gene MTM1
Long gene name myotubularin 1
Synonyms gene name myotubular myopathy 1
Locus Xq28
Discovery year 2001-06-22
GenBank acession U46024
Entrez gene record 4534
RefSeq identity NM_000252
Classification Phosphoinositide phosphatases Myotubularins
Havana BLAST/BLAT OTTHUMG00000024158
Locus Specific Databases Leiden Muscular Dystrophy pages Mental Retardation database LRG_839

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