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MTM1 Antibody, ALEXA FLUOR 555

MTM1 Antibody, ALEXA FLUOR 555 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 555 Conjugated, MTM1 Polyclonal Antibody
Also known asAnti-MTM1 PAb ALEXA FLUOR 555
CategoryConjugated Primary Antibodies
Conjugated with 555, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenMTM1
SpecificityThis is a highly specific antibody against MTM1
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MTM1/Myotubularin
Gene ID Number4534
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen Human MTM1, Myotubularin is primarily a lipid phosphatase that acts on phosphatidylinositol 3-monophosphate and is involved in the regulation of the phosphatidylinositol 3-kinase (PI3-kinase) pathway and membrane trafficking, The gene for MTM1 is localized to a 300 kb critical region on human Xq128 between IDS and GRBRA3, The gene responsible for myotubular myopathy MTM1 encodes a dual specificity phosphatase, The largely related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-Tooth neuropathy, Thus, Wild-type myotubularin can directly dephosphorylate PI3P and PI4P in vitro, a 603 amino-acid protein, in most cases, is mutated in myotubular myopathy, it decreases PI3P levels by down-regulating PI3K activity and by facilitating the degradation of PI3P, leads to early postnatal death, named myotubularin, which is highly conserved through evolution, X-linked recessive myotubular myopathy is a congenital muscular disease characterized by severe hypotonia and generalized muscle weakness that
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission553nm/568nm
Properties ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 555, Alexa Fluor
Gene targetMTM1
Short nameMTM1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 555
Alternative name ALEXA FLUOR 555, MTM1 (Antibody to)
Alternative techniqueantibodies
Identity 7448
Gene MTM1
Long gene name myotubularin 1
Synonyms gene name myotubular myopathy 1
Locus Xq28
Discovery year 2001-06-22
GenBank acession U46024
Entrez gene record 4534
RefSeq identity NM_000252
Classification Phosphoinositide phosphatases Myotubularins
Havana BLAST/BLAT OTTHUMG00000024158
Locus Specific Databases Leiden Muscular Dystrophy pages Mental Retardation database LRG_839

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