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Mtp53 (N235K N239Y) Antibody

Mtp53 (N235K N239Y) Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameMtp53 (N235K N239Y) Primary Polyclonal Antibody
Also known asMtp53 (N235K N239Y) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenMtp53 N235K N239Y
SpecificityThis is a highly specific antibody against Mtp53 N235K N239Y
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range210-260/393
Subcellular location Nucleus, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Mtp53 around N235K N239Y
Gene ID number7157
Swiss ProtP04637
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivityHuman
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, Implicated in Notch signaling cross-over, In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis, Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1, Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process, Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters, Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1, Isoform 7 inhibits isoform 1-mediated apoptosis, LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation, One of the activated genes is an inhibitor of cyclin-dependent kinases, Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, induces growth arrest or apoptosis depending on the physiological circumstances and cell type, or by repression of Bcl-2 expression, the function is largely independent of transcription, thus stopping cell cycle progression, Acts as a tumor suppressor in many tumor types
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Antigen NY-CO-13, BCC7, Cellular tumor antigen p53, LFS1, Phosphoprotein p53, TP53, TRP53, Tumor suppressor p53, P53
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetMtp53 (N235K N239Y)
Short nameMtp53 (N235K N239Y) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameMtp53 (N235K N239Y) (Antibody to)
Alternative techniqueantibodies

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