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MUC4 Antibody, Cy7 Conjugated

MUC4 Antibody, Cy7 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy7 Conjugated, MUC4 Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationCy7
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenMUC4
SpecificityThis is a highly specific antibody against MUC4
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen_range1240-1290/2169
Subcellular location Cell membrane, Secreted
SourceKLH conjugated synthetic peptide derived from human Mucin-4 alpha chain
Gene ID number4585
Swiss ProtQ99102
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation, Has anti-adhesive properties, In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor, Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2, Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2, The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248', The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, The interaction with ERBB2 leads to enhanced expression of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation, May play a role in tumor progression
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission743nm/767nm
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths
Gene targetMUC4 Conjugated
Short name Conjugated, MUC4 Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy7
Alternative name cellular surface associated (Antibody to), cyanine 7 coupled, mucin 4
Alternative techniqueantibodies
Alternative to gene target ASGP and HSA276359 and MUC-4, Extracellular, MUC4 and IDBG-633795 and ENSBTAG00000014721 and, MUC4 and IDBG-70699 and ENSG00000145113 and 4585, Muc4 and IDBG-250337 and ENSMUSG00000079620 and 140474, cell surface associated, extracellular matrix constituent, lubricant activity, lubricant activity, lubricant activity and molecular function this GO :0030277 and maintenance of gastrointestinal epithelium and biological process this GO :0043687 and post-translational protein modification and biological process this GO :0044267 and cellular protein metabolic process and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0002244 and hematopoietic progenitor cell differentiation and biological process this GO :0005176 and ErbB-2 class receptor binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005578 and proteinaceous extracellular matrix and cellular component this GO :0005615 and extracellular space and cellular component this GO :0005796 and this GO lgi lumen and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0007160 and cell-matrix adhesion and biological process this GO :0016020 and membrane and cellular component this GO :0016266 and O-glycan processing and biological process this GO :0030197 and extracellular matrix constituent, this GO :0005176: ErbB-2 class receptor binding, this GO :0005176: ErbB-2 class receptor binding and also this GO :0005515: protein binding and also this GO :0030197: extracellular matrix constituent, this GO :0005515: protein binding, this GO :0030197: extracellular matrix constituent, mucin 4
Identity 7514
Gene MUC4
Long gene name cell surface associated , mucin 4
Synonyms gene name mucin 4, tracheobronchial
Locus 3q29
Discovery year 1991-05-22
GenBank acession AJ276359
Entrez gene record 4585
Pubmed identfication 1673336
RefSeq identity NM_018406
Classification Mucins
Havana BLAST/BLAT OTTHUMG00000151827

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