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Mucin 4 Antibody

Mucin 4 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameMucin 4 Primary Polyclonal Antibody
Also known asMucin 4 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenMucin 4
SpecificityThis is a highly specific antibody against Mucin 4
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range1580-1630/2169
Subcellular location Cell membrane, Secreted
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Muc4
Gene ID number4585
Swiss ProtQ99102
Tested Applications IF(IHC-P), IHC-P
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation, Has anti-adhesive properties, In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor, Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2, Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2, The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248', The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, The interaction with ERBB2 leads to enhanced expression of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation, May play a role in tumor progression
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names Ascites sialoglycoprotein, HSA276359, MUC-4, MUC4, Mucin-4, Pancreatic adenocarcinoma mucin, Testis mucin, Tracheobronchial mucin, ASGP
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetMucin 4
Short nameMucin 4 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameMucin 4 (Antibody to)
Alternative techniqueantibodies
Identity 25132
Gene TIMD4
Long gene name T-cell immunoglobulin and mucin domain containing 4
Locus 5q33, 3
Discovery year 2004-07-22
GenBank acession BC008988
Entrez gene record 91937
Pubmed identfication 12477932
RefSeq identity NM_138379
Classification V-set domain containing
Havana BLAST/BLAT OTTHUMG00000130244

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