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MUSK Antibody, ALEXA FLUOR 350

MUSK Antibody, ALEXA FLUOR 350 size: 100ul 332

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES
Price 332
Size 100ul
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name ALEXA FLUOR 350 Conjugated, MUSK Polyclonal Antibody
Also known asAnti-MUSK PAb ALEXA FLUOR 350
CategoryConjugated Primary Antibodies
Conjugated with 350, ALEXA FLUOR®
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenMUSK
SpecificityThis is a highly specific antibody against MUSK
ModificationUnmodified
Modification SiteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
Immunogen range260-310/869
Subcellular locationExtracellular
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MUSK
Gene ID Number4593
Swiss ProtO15146
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Cross-reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering, May also play a role within the central nervous system by mediating cholinergic responses, May positively regulate Rho family GTPases through FNTA, May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK, Mediates the phosphorylation of FNTA which promotes prenylation, Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK, Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression, synaptic plasticity and memory formation (By similarity), the kinase of the complex, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane, the synapse between the motor neuron and the skeletal muscle (PubMed:25537362), Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ)
PurificationPurified by Protein A
Storage conditions 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission343nm/442nm
Properties ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation ALEXA FLUOR 350, Alexa Fluor
Gene targetMUSK
Short nameMUSK Antibody
Technique antibodies against human proteins, antibodies for, Antibody
LabelALEXA FLUOR 350
Alternative name ALEXA FLUOR 350, MUSK (Antibody to)
Alternative techniqueantibodies
Identity 7525
Gene MUSK
Long gene name muscle associated receptor tyrosine kinase
Synonyms gene name muscle, receptor tyrosine kinase , skeletal
Locus 9q31, 3
Discovery year 1997-04-10
GenBank acession AF006464
Entrez gene record 4593
Pubmed identfication 7546737
Classification I-set domain containing Immunoglobulin like domain containing Receptor Tyrosine Kinases
Havana BLAST/BLAT OTTHUMG00000020485

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