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NARC1 Antibody

NARC1 Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameNARC1 Primary Polyclonal Antibody
Also known asNARC1 PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenNARC1
SpecificityThis is a highly specific antibody against NARC1
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range235-285/692
Subcellular location Lysosome, Secreted, Cytoplasm
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human PCSK9/NARC1
Gene ID number255738
Swiss ProtQ8NBP7
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway, Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), Can induce ubiquitination of LDLR leading to its subsequent degradation (PubMed:18799458, Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation, Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner, Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway (PubMed:18660751), May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation, PubMed:17461796, PubMed:18197702, PubMed:22074827), Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways, and promotes their degradation in intracellular acidic compartments (PubMed:18039658), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), very low density lipoprotein receptor (VLDLR), Crucial player in the regulation of plasma cholesterol homeostasis
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names HCHOLA3, LDLCQ1, NARC-1, NARC1, Neural apoptosis-regulated convertase 1, PC9, PCSK9, PSEC0052, Proprotein convertase 9, Proprotein convertase subtilisin/kexin type 9, Subtilisin/kexin-like protease PC9, FH3
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetNARC1
Short nameNARC1 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameNARC1 (Antibody to)
Alternative techniqueantibodies

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