| Long name | ALEXA FLUOR 647 Conjugated, NCF1/p47 phox(Ser359) Antibody |
| Also known as | Anti-NCF1/p47 phox Ser359 PAb ALEXA FLUOR 647 |
| Category | Conjugated Primary Antibodies |
| Conjugated with | 647, ALEXA FLUOR® |
| Host Organism | Rabbit (Oryctolagus cuniculus) |
| Target Antigen | NCF1/p47 phox Ser359 |
| Specificity | This is a highly specific antibody against NCF1/p47 phox Ser359 |
| Modification | Phosphorylation |
| Modification Site | Ser359 |
| Clonality | Polyclonal |
| Clone | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Source | KLH conjugated synthetic phosphopeptide derived from human NCF1 around the phosphorylation site of Ser359 |
| Gene ID Number | 653361 |
| Tested applications | IF(IHC-P) |
| Recommended dilutions | IF(IHC-P)(1:50-200) |
| Crossreactivity | Rat, Human |
| Cross-reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen | Both p47-phox and p67-phox contain two Src homology 3 (SH3) domains, During activation of the NADPH oxidase, The C-terminal SH3 domain of p67-phox has been shown to interact with the proline-rich domain of p47-phox, The cytosolic proteins p47-phox and p67-phox, also designated neutrophil cytosol factor (NCF)1 and NCF2, are required for activation of the superoxide-producing NADPH oxidase in neutrophils and other phagocytic cells, p47-phox and p67-phox migrate to the plasma membrane where they associate with cytochrome b558 and the small G protein Rac to form the functional enzyme complex, respectively, suggesting that p47-phox may faciliate the transport of p67-phox to the membrane, The heredity chronic granulomatous disease (CGF) has been linked to mutations in p47-phox and p67-phox |
| Purification | Purified by Protein A |
| Storage conditions | 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission | 650nm/665nm |
| Synonyms | p47phox NOXO2 NCF1A SH3PXD1A |
| Properties | ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the NCF1/p47 phox(Ser359) Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation | ALEXA FLUOR 647, Alexa Fluor |
| Gene target | NCF1/p47 phox(Ser359) |
| Short name | NCF1/p47 phox(Ser359) Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Label | ALEXA FLUOR 647 |
| Alternative name | ALEXA FLUOR 647, neutrophil cytosolic factor 1/p47 phox(Ser359) (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | NCF1 and IDBG-21570 and ENSG00000158517 and 653361, NCF1 and IDBG-639883 and ENSBTAG00000003305 and 281345, Ncf1 and IDBG-202592 and ENSMUSG00000015950 and 17969, Plasma membranes, TAP-dependent and biological process this GO :0002679 and respiratory burst involved in defense response and biological process this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0005791 and rough endoplasmic reticulum and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006612 and protein targeting to membrane and biological process this GO :0006691 and leukotriene metabolic process and biological process this GO :0006801 and superoxide metabolic process and biological process this GO :0006915 and apoptotic process and biological process this GO :0006954 and inflammatory response and biological process this GO :0006968 and cellular defense response and biological process this GO :0008283 and cell proliferation and biological process this GO :0009055 and electron carrier activity and molecular function this GO :0009617 and response to bacterium and biological process this GO :0016020 and membrane and cellular component this GO :0016175 and superoxide-generating NADPH oxidase activity and molecular function this GO :0017124 and SH3 domain binding and molecular function this GO :0019898 and extrinsic component of membrane and cellular component this GO :0030425 and dendrite and cellular component this GO :0032010 and pha this GO lysosome and cellular component this GO :0035091 and phosphatidylinositol binding and molecular function this GO :0042554 and superoxide anion generation and biological process this GO :0042590 and antigen processing and presentation of exogenous peptide antigen via MHC class I and biological process this GO :0042742 and defense response to bacterium and biological process this GO :0043020 and NADPH oxidase complex and cellular component this GO :0043025 and neuronal cell body and cellular component this GO :0043325 and phosphatidylinositol-3, phosphatidylinositol-3, this GO :0001878 and response to yeast and biological process this GO :0001909 and leukocyte mediated cytotoxicity and biological process this GO :0002474 and antigen processing and presentation of peptide antigen via MHC class I and biological process this GO :0002479 and antigen processing and presentation of exogenous peptide antigen via MHC class I, this GO :0005515: protein binding, this GO :0005515: protein binding and also this GO :0009055: electron carrier activity and also this GO :0016175: superoxide-generating NADPH oxidase activity and also this GO :0017124: SH3 domain binding and also this GO :0035091: phosphatidylinositol binding and also this GO :0043325: phosphatidylinositol-3, this GO :0009055: electron carrier activity, this GO :0016175: superoxide-generating NADPH oxidase activity, this GO :0017124: SH3 domain binding, this GO :0035091: phosphatidylinositol binding, this GO :0043325: phosphatidylinositol-3, 4-bisphosphate binding, 4-bisphosphate binding, 4-bisphosphate binding and molecular function this GO :0045087 and innate immune response and biological process this GO :0045730 and respiratory burst and biological process this GO :0045986 and negative regulation of smooth muscle contraction and biological process this GO :0050665 and hydrogen peroxide biosynthetic process and biological process this GO :0050830 and defense response to Gram-positive bacterium and biological process this GO :0050832 and defense response to fungus and biological process this GO :0051701 and interaction with host and biological process this GO :0055114 and oxidation-reduction process and biological process this GO :0070946 and neutrophil mediated killing of gram-positive bacterium and biological process this GO :0070947 and neutrophil mediated killing of fungus and biological process this GO :0090382 and pha this GO some maturation and biological process, neutrophil cytosolic factor 1 |
| Identity | 7660 |
| Gene | NCF1 |
| Long gene name | neutrophil cytosolic factor 1 |
| Synonyms gene name | autosomal 1) , chronic granulomatous disease, neutrophil cytosolic factor 1 (47kD |
| Synonyms name | NADPH oxidase organizer 2 chronic granulomatous disease, autosomal 1 |
| Locus | 7q11, 23 |
| Discovery year | 1989-05-25 |
| GenBank acession | M25665 |
| Entrez gene record | 653361 |
| RefSeq identity | NM_000265 |
| Havana BLAST/BLAT | OTTHUMG00000149965 |
| Locus Specific Databases | NCF1base: Mutation registry for autosomal recessive chronic granulomatous disease (CGD), deficiency of p47phox LRG_87 |
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