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Neurabin 1/PPP1R9A Antibody

Neurabin 1/PPP1R9A Antibody size: 0.1ml 263

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 263
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameNeurabin 1/PPP1R9A Primary Polyclonal Antibody
Also known asNeurabin 1/PPP1R9A PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenNeurabin 1/PPP1R9A
SpecificityThis is a highly specific antibody against Neurabin 1/PPP1R9A
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
SourceThis antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Neurabin 1
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Neurabin I recruits active PP1 via a PP1-docking sequence, Neurabin II (Spinophilin) is ubiquitously expressed but is abundantly expressed in brain (4), Neurabin II complexes with the catalytic subunit of protein phosphatase-1 (PP1) in vitro thus modulating the activity of PP1 (4), Neurabin II localizes to neuronal dentritic spines, Neurabin II may regulate dendritic spine properties as neurabin II(-) mice have increased spine density during development in vitro and exhibit altered filopodial formation in cultured cells (5), Neurabin may also play a role in glutamatergic transmission as Neurabin II(-) mice exhibit reduced long-term depression and resistance to kainate-induced seizures and neronal apoptosis (5), Suppression of endogenous neurabin in rat hippocampal neurons inhibits neurite formation (1), it localizes in the growth cone lamellipodia during neuronal development (1), mutation of the PP1-binding motif halts filopodia and restores stress fibers in neurabin I-expressing cells (2, which are the specialized protrusions from dendritic shafts that receive most of the excitatory input in the CNS (5), 3), Brain-specific neurabin I (neural tissue-specific F-actin binding protein I) is highly concentrated in the synapse of developed neurons
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names KIAA1222, NEB1_HUMAN, NRB 1, NRB I, NRB1, NRBI, Neurabin I, Neurabin-1, Neurabin-1, Neurabin-I, Neurabin1, Neurabin1, NeurabinI, Neural tissue specic F actin binding protein I, Neural tissue-specic F-actin-binding protein I, PPP1R9A, Protein phosphatase 1 regulatory inhibitor subunit 9A, Protein phosphatase 1 regulatory subunit 9A, FLJ20068
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetNeurabin 1/PPP1R9A
Short nameNeurabin 1/PPP1R9A Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameNeurabin 1/PPP1R9A (Antibody to)
Alternative techniqueantibodies
Identity 14946
Gene PPP1R9A
Long gene name protein phosphatase 1 regulatory subunit 9A
Synonyms gene name protein phosphatase 1, regulatory (inhibitor) subunit 9A protein phosphatase 1, regulatory subunit 9A
Synonyms Neurabin-I KIAA1222 FLJ20068
Locus 7q21, 3
Discovery year 2001-06-29
GenBank acession AB033048
Entrez gene record 55607
Pubmed identfication 10574462
RefSeq identity NM_001166160
Classification Sterile alpha motif domain containing Protein phosphatase 1 regulatory subunits PDZ domain containing
Havana BLAST/BLAT OTTHUMG00000155566

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