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Neurabin 1/PPP1R9A Antibody, Cy7 Conjugated

Neurabin 1/PPP1R9A Antibody, Cy7 Conjugated size: 0.1ml 350

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 350
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy7 Conjugated, Neurabin 1/PPP1R9A Polyclonal Antibody
CategoryConjugated Primary Antibodies
ConjugationCy7
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenNeurabin 1/PPP1R9A
SpecificityThis is a highly specific antibody against Neurabin 1/PPP1R9A
ModificationUnmodified
Modification siteNone
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic peptide derived from human Neurabin 1
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Neurabin I recruits active PP1 via a PP1-docking sequence, Neurabin II (Spinophilin) is ubiquitously expressed but is abundantly expressed in brain (4), Neurabin II complexes with the catalytic subunit of protein phosphatase-1 (PP1) in vitro thus modulating the activity of PP1 (4), Neurabin II localizes to neuronal dentritic spines, Neurabin II may regulate dendritic spine properties as neurabin II(-) mice have increased spine density during development in vitro and exhibit altered filopodial formation in cultured cells (5), Neurabin may also play a role in glutamatergic transmission as Neurabin II(-) mice exhibit reduced long-term depression and resistance to kainate-induced seizures and neronal apoptosis (5), Suppression of endogenous neurabin in rat hippocampal neurons inhibits neurite formation (1), it localizes in the growth cone lamellipodia during neuronal development (1), mutation of the PP1-binding motif halts filopodia and restores stress fibers in neurabin I-expressing cells (2, which are the specialized protrusions from dendritic shafts that receive most of the excitatory input in the CNS (5), 3), Brain-specific neurabin I (neural tissue-specific F-actin binding protein I) is highly concentrated in the synapse of developed neurons
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission743nm/767nm
Synonyms Neurabin-I KIAA1222 FLJ20068
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
ConjugatedThese antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths
Gene targetNeurabin 1/PPP1R9A Conjugated
Short name Conjugated, Neurabin 1/PPP1R9A Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy7
Alternative name cyanine 7 coupled, Neurabin 1/PPP1R9A (Antibody to)
Alternative techniqueantibodies
Identity 14946
Gene PPP1R9A
Long gene name protein phosphatase 1 regulatory subunit 9A
Synonyms gene name protein phosphatase 1, regulatory (inhibitor) subunit 9A protein phosphatase 1, regulatory subunit 9A
Locus 7q21, 3
Discovery year 2001-06-29
GenBank acession AB033048
Entrez gene record 55607
Pubmed identfication 10574462
RefSeq identity NM_001166160
Classification Sterile alpha motif domain containing Protein phosphatase 1 regulatory subunits PDZ domain containing
Havana BLAST/BLAT OTTHUMG00000155566

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