| Long name | NF1 Primary Polyclonal Antibody |
| Also known as | NF1 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | NF1 |
| Specificity | This is a highly specific antibody against NF1 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Neurofibromin 1 |
| Gene ID number | 4763 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Alternatively spliced transcript variants encoding different isoforms have also been described for this gene, Jul 2008], Mutations in this gene have been linked to neurofibromatosis type 1, The mRNA for this gene is subject to RNA editing (CGA>, [provided by RefSeq, juvenile myelomonocytic leukemia and Watson syndrome, Arg1306Term) resulting in premature translation termination, This gene product appears to function as a negative regulator of the ras signal transduction pathway, UGA-> |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | DKFZp686J1293, FLJ21220, NF, NF 1, NF1, NF1_HUMAN, NFNS, Neurofibromatosis Noonan syndrome, Neurofibromatosis related protein NF 1, Neurofibromatosis related protein NF1, Neurofibromatosis-related protein NF-1, Neurofibromin 1, Neurofibromin truncated, Neurofibromin1, Type 1 Neurofibromatosis, VRNF, WATS, WSS, Watson disease related protein WSS, Watson syndrome, neurofibromatosis type I, von Recklinghausen disease neurofibromin, von Recklinghausen disease related protein VRNF, Neurofibromin 1 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | NF1 |
| Short name | NF1 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | neurofibromin 1 (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | GABAergic and biological process this GO :0032318 and regulation of Ras GTPase activity and biological process this GO :0032320 and positive regulation of Ras GTPase activity and biological process this GO :0035021 and negative regulation of Rac protein signal transduction and biological process this GO :0042060 and wound healing and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042992 and negative regulation of transcription factor import into nucleus and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043407 and negative regulation of MAP kinase activity and biological process this GO :0043409 and negative regulation of MAPK cascade and biological process this GO :0043473 and pigmentation and biological process this GO :0043525 and positive regulation of neuron apoptotic process and biological process this GO :0043535 and regulation of blood vessel endothelial cell migration and biological process this GO :0045124 and regulation of bone resorption and biological process this GO :0045671 and negative regulation of osteoclast differentiation and biological process this GO :0045685 and regulation of glial cell differentiation and biological process this GO :0045762 and positive regulation of adenylate cyclase activity and biological process this GO :0045765 and regulation of angiogenesis and biological process this GO :0046580 and negative regulation of Ras protein signal transduction and biological process this GO :0046929 and negative regulation of neurotransmitter secretion and biological process this GO :0048147 and negative regulation of fibroblast proliferation and biological process this GO :0048169 and regulation of long-term neuronal synaptic plasticity and biological process this GO :0048485 and sympathetic nervous system development and biological process this GO :0048593 and camera-type eye morphogenesis and biological process this GO :0048712 and negative regulation of astrocyte differentiation and biological process this GO :0048715 and negative regulation of oli this GO dendrocyte differentiation and biological process this GO :0048745 and smooth muscle tissue development and biological process this GO :0048844 and artery morphogenesis and biological process this GO :0048853 and forebrain morphogenesis and biological process this GO :0050890 and cognition and biological process this GO :0051056 and regulation of small GTPase mediated signal transduction and biological process this GO :1902043 and positive regulation of extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :2001241 and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process, NF1 and IDBG-39462 and ENSG00000196712 and 102725369, NF1 and IDBG-631285 and ENSBTAG00000011829 and 280877, NFNS and VRNF and WSS, Nf1 and IDBG-203454 and ENSMUSG00000020716 and 18015, nuclei, phosphatidylcholine binding, this GO :0000165 and MAPK cascade and biological process this GO :0001649 and osteoblast differentiation and biological process this GO :0001656 and metanephros development and biological process this GO :0001666 and response to hypoxia and biological process this GO :0001889 and liver development and biological process this GO :0001937 and negative regulation of endothelial cell proliferation and biological process this GO :0001938 and positive regulation of endothelial cell proliferation and biological process this GO :0001952 and regulation of cell-matrix adhesion and biological process this GO :0001953 and negative regulation of cell-matrix adhesion and biological process this GO :0005096 and GTPase activator activity and molecular function this GO :0005099 and Ras GTPase activator activity and molecular function this GO :0005488 and binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006469 and negative regulation of protein kinase activity and biological process this GO :0007154 and cell communication and biological process this GO :0007165 and signal transduction and biological process this GO :0007265 and Ras protein signal transduction and biological process this GO :0007406 and negative regulation of neuroblast proliferation and biological process this GO :0007420 and brain development and biological process this GO :0007422 and peripheral nervous system development and biological process this GO :0007507 and heart development and biological process this GO :0007519 and skeletal muscle tissue development and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008429 and phosphatidylethanolamine binding and molecular function this GO :0008542 and visual learning and biological process this GO :0008625 and extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :0014044 and Schwann cell development and biological process this GO :0014065 and phosphatidylinositol 3-kinase signaling and biological process this GO :0016020 and membrane and cellular component this GO :0016525 and negative regulation of angiogenesis and biological process this GO :0021510 and spinal cord development and biological process this GO :0021897 and forebrain astrocyte development and biological process this GO :0021915 and neural tube development and biological process this GO :0021987 and cerebral cortex development and biological process this GO :0022011 and myelination in peripheral nervous system and biological process this GO :0030036 and actin cytoskeleton organization and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0030199 and collagen fibril organization and biological process this GO :0030325 and adrenal gland development and biological process this GO :0030336 and negative regulation of cell migration and biological process this GO :0030424 and axon and cellular component this GO :0030425 and dendrite and cellular component this GO :0031210 and phosphatidylcholine binding and molecular function this GO :0031235 and intrinsic component of the cytoplasmic side of the plasma membrane and cellular component this GO :0032228 and regulation of synaptic transmission, this GO :0005096: GTPase activator activity, this GO :0005096: GTPase activator activity and also this GO :0005099: Ras GTPase activator activity and also this GO :0005488: binding and also this GO :0005515: protein binding and also this GO :0008429: phosphatidylethanolamine binding and also this GO :0031210: phosphatidylcholine binding, this GO :0005099: Ras GTPase activator activity, this GO :0005488: binding, this GO :0005515: protein binding, this GO :0008429: phosphatidylethanolamine binding, this GO :0031210: phosphatidylcholine binding, 4763, neurofibromin 1 |
| Identity | 7765 |
| Gene | NF1 |
| Long gene name | neurofibromin 1 |
| Synonyms name | neurofibromatosis von Recklinghausen disease Watson disease |
| Locus | 17q11, 2 |
| Discovery year | 1986-01-01 |
| Entrez gene record | 4763 |
| Pubmed identfication | 1715669 |
| RefSeq identity | NM_000267 |
| Havana BLAST/BLAT | OTTHUMG00000132871 |
| Locus Specific Databases | LOVD - Mendelian genes LRG_214 |
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