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NF2/Merlin (AF1G4) Monoclonal Antibody

NF2/Merlin (AF1G4) Monoclonal Antibody size: 0.1ml 362

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 362
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameNF2/Merlin (AF1G4) Monoclonal Antibody
Also known asNF2/Merlin (AF1G4) Monoclonal Antibody
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenNF2/Merlin
SpecificityThis is a highly specific antibody against NF2/Merlin
Modification(s)None
Modification site(s)Unmodified antibody
ClonalityMonoclonal
Clone numberAF1G4
Concentration1ug per 1ul
SourceRecombinant human protein purified from E, coli (His-Merlin)
Gene ID number4771
Swiss ProtP35240
Tested ApplicationsWB
Recommended dilutions5 ug/ml), WB (0
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, May act as a membrane stabilizing protein, May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity, Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis, Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway
Purification methodPurified by Protein G
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names BANF, Merlin, Moesin-ezrin-radixin-like protein, NF2, Neurofibromin-2, SCH, Schwannomerlin, Schwannomin, ACN
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
About Each murine monoclonal anibody has his own affinity specific for the clone, Mouse monoclonal antibodies are purified protein A or G and can be conjugated to FITC for flow cytometry or FACS and can be of different isotypes, Monoclonals of this antigen are available in different clones
Gene targetNF2/Merlin (AF1G4) Monoclonal
Short nameNF2/Merlin (AF1G4) Monoclonal Antibody
Technique Monoclonals or monoclonal antibodies, antibodies against human proteins, antibodies for, Antibody
Alternative nameneurofibromin 2 (merlin)/Merlin (AF1G4) monoclonal (Antibody to)
Alternative techniqueantibodies
Alternative to gene target ACN and BANF and SCH, NF2 and IDBG-3678 and ENSG00000186575 and 4771, NF2 and IDBG-636202 and ENSBTAG00000013153 and 540479, Nf2 and IDBG-142996 and ENSMUSG00000009073 and 18016, cytoskeletal protein binding, nuclei, this GO :0001707 and mesoderm formation and biological process this GO :0001726 and ruffle and cellular component this GO :0001953 and negative regulation of cell-matrix adhesion and biological process this GO :0003779 and actin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005769 and early endosome and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005912 and adherens junction and cellular component this GO :0006469 and negative regulation of protein kinase activity and biological process this GO :0007398 and ectoderm development and biological process this GO :0007420 and brain development and biological process this GO :0008092 and cytoskeletal protein binding and molecular function this GO :0008156 and negative regulation of DNA replication and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0014010 and Schwann cell proliferation and biological process this GO :0016020 and membrane and cellular component this GO :0019898 and extrinsic component of membrane and cellular component this GO :0021766 and hippocampus development and biological process this GO :0022408 and negative regulation of cell-cell adhesion and biological process this GO :0030027 and lamellipodium and cellular component this GO :0030036 and actin cytoskeleton organization and biological process this GO :0030175 and filopodium and cellular component this GO :0030336 and negative regulation of cell migration and biological process this GO :0030864 and cortical actin cytoskeleton and cellular component this GO :0031527 and filopodium membrane and cellular component this GO :0031647 and regulation of protein stability and biological process this GO :0032154 and cleavage furrow and cellular component this GO :0032587 and ruffle membrane and cellular component this GO :0035330 and regulation of hippo signaling and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042475 and odontogenesis of dentin-containing tooth and biological process this GO :0042518 and negative regulation of tyrosine phosphorylation of Stat3 protein and biological process this GO :0042524 and negative regulation of tyrosine phosphorylation of Stat5 protein and biological process this GO :0043409 and negative regulation of MAPK cascade and biological process this GO :0045177 and apical part of cell and cellular component this GO :0045216 and cell-cell junction organization and biological process this GO :0045597 and positive regulation of cell differentiation and biological process this GO :0046426 and negative regulation of JAK-STAT cascade and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0051496 and positive regulation of stress fiber assembly and biological process this GO :0070306 and lens fiber cell differentiation and biological process this GO :1900180 and regulation of protein localization to nucleus and biological process this GO :2000177 and regulation of neural precursor cell proliferation and biological process, this GO :0003779: actin binding, this GO :0003779: actin binding and also this GO :0005515: protein binding and also this GO :0008092: cytoskeletal protein binding, this GO :0005515: protein binding, this GO :0008092: cytoskeletal protein binding, neurofibromin 2 (merlin)
Identity 7773
Gene NF2
Long gene name neurofibromin 2
Synonyms gene name neurofibromin 2 (bilateral acoustic neuroma) neurofibromin 2 (merlin)
Synonyms merlin ACN SCH BANF
Synonyms name moesin-ezrin-radixin like schwannomin
Locus 22q12, 2
Discovery year 1992-01-01
GenBank acession L11353
Entrez gene record 4771
Pubmed identfication 10591208
RefSeq identity NM_000268
Classification A-kinase anchoring proteins FERM domain containing
Havana BLAST/BLAT OTTHUMG00000030727
Locus Specific Databases Neurofibromatosis 2 (NF2) mutation database LRG_511

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