| Long name | ALEXA FLUOR 488 Conjugated, NF2/Neurofibromin 2 Polyclonal Antibody |
| Also known as | Anti-NF2/Neurofibromin 2 PAb ALEXA FLUOR 488 |
| Category | Conjugated Primary Antibodies |
| Conjugated with | 488, ALEXA FLUOR® |
| Host Organism | Rabbit (Oryctolagus cuniculus) |
| Target Antigen | NF2/Neurofibromin 2 |
| Specificity | This is a highly specific antibody against NF2/Neurofibromin 2 |
| Modification | Unmodified |
| Modification Site | None |
| Clonality | Polyclonal |
| Clone | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 430-480/590 |
| Subcellular location | Intracellular |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NF2 |
| Gene ID Number | 4771 |
| Swiss Prot | P35240 |
| Tested applications | IF(IHC-P) |
| Recommended dilutions | IF(IHC-P)(1:50-200) |
| Crossreactivity | Mouse, Rat, Human |
| Cross-reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen | Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, May act as a membrane stabilizing protein, May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity, Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis, Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway |
| Purification | Purified by Protein A |
| Storage conditions | 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission | 499nm/519nm |
| Synonyms | merlin ACN SCH BANF |
| Properties | ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the NF2/Neurofibromin 2 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation | Alexa Fluor |
| Gene target | NF2/Neurofibromin 2 |
| Short name | NF2/Neurofibromin 2 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Label | ALEXA FLUOR 488 |
| Alternative name | ALEXA FLUOR 488, neurofibromin 2 (merlin)/Neurofibromin 2 (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | ACN and BANF and SCH, NF2 and IDBG-3678 and ENSG00000186575 and 4771, NF2 and IDBG-636202 and ENSBTAG00000013153 and 540479, Nf2 and IDBG-142996 and ENSMUSG00000009073 and 18016, cytoskeletal protein binding, nuclei, this GO :0001707 and mesoderm formation and biological process this GO :0001726 and ruffle and cellular component this GO :0001953 and negative regulation of cell-matrix adhesion and biological process this GO :0003779 and actin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005769 and early endosome and cellular component this GO :0005856 and cytoskeleton and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005912 and adherens junction and cellular component this GO :0006469 and negative regulation of protein kinase activity and biological process this GO :0007398 and ectoderm development and biological process this GO :0007420 and brain development and biological process this GO :0008092 and cytoskeletal protein binding and molecular function this GO :0008156 and negative regulation of DNA replication and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0014010 and Schwann cell proliferation and biological process this GO :0016020 and membrane and cellular component this GO :0019898 and extrinsic component of membrane and cellular component this GO :0021766 and hippocampus development and biological process this GO :0022408 and negative regulation of cell-cell adhesion and biological process this GO :0030027 and lamellipodium and cellular component this GO :0030036 and actin cytoskeleton organization and biological process this GO :0030175 and filopodium and cellular component this GO :0030336 and negative regulation of cell migration and biological process this GO :0030864 and cortical actin cytoskeleton and cellular component this GO :0031527 and filopodium membrane and cellular component this GO :0031647 and regulation of protein stability and biological process this GO :0032154 and cleavage furrow and cellular component this GO :0032587 and ruffle membrane and cellular component this GO :0035330 and regulation of hippo signaling and biological process this GO :0042127 and regulation of cell proliferation and biological process this GO :0042475 and odontogenesis of dentin-containing tooth and biological process this GO :0042518 and negative regulation of tyrosine phosphorylation of Stat3 protein and biological process this GO :0042524 and negative regulation of tyrosine phosphorylation of Stat5 protein and biological process this GO :0043409 and negative regulation of MAPK cascade and biological process this GO :0045177 and apical part of cell and cellular component this GO :0045216 and cell-cell junction organization and biological process this GO :0045597 and positive regulation of cell differentiation and biological process this GO :0046426 and negative regulation of JAK-STAT cascade and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0051496 and positive regulation of stress fiber assembly and biological process this GO :0070306 and lens fiber cell differentiation and biological process this GO :1900180 and regulation of protein localization to nucleus and biological process this GO :2000177 and regulation of neural precursor cell proliferation and biological process, this GO :0003779: actin binding, this GO :0003779: actin binding and also this GO :0005515: protein binding and also this GO :0008092: cytoskeletal protein binding, this GO :0005515: protein binding, this GO :0008092: cytoskeletal protein binding, neurofibromin 2 (merlin) |
| Identity | 7773 |
| Gene | NF2 |
| Long gene name | neurofibromin 2 |
| Synonyms gene name | neurofibromin 2 (bilateral acoustic neuroma) neurofibromin 2 (merlin) |
| Synonyms name | moesin-ezrin-radixin like schwannomin |
| Locus | 22q12, 2 |
| Discovery year | 1992-01-01 |
| GenBank acession | L11353 |
| Entrez gene record | 4771 |
| Pubmed identfication | 10591208 |
| RefSeq identity | NM_000268 |
| Classification | A-kinase anchoring proteins FERM domain containing |
| Havana BLAST/BLAT | OTTHUMG00000030727 |
| Locus Specific Databases | Neurofibromatosis 2 (NF2) mutation database LRG_511 |
Technique
Supplier
Species
Label
Iso Type
Host
Tissue