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NFAT5 (Ser1197) Antibody, Cy3 Conjugated

NFAT5 (Ser1197) Antibody, Cy3 Conjugated size: 0.1ml 368

Supplier BIOSS PRIMARY CONJUGATED ANTIBODIES 1
Price 368
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long name Cy3 Conjugated, NFAT5 (Ser1197) Polyclonal Antibody
CategoryConjugated Primary Antibodies
Conjugationcy3 conjugation kit
Host OrganismRabbit (Oryctolagus cuniculus)
Target AntigenNFAT5 Ser1197
SpecificityThis is a highly specific antibody against NFAT5 Ser1197
ModificationPhosphorylation
Modification siteSer1197
ClonalityPolyclonal
ClonePolyclonal antibody
Concentration1ug per 1ul
SourceKLH conjugated synthetic phosphopeptide derived from human NFAT5 around the phosphorylation site of Ser1197
Gene ID number10725
Tested applicationsIF(IHC-P)
Recommended dilutionsIF(IHC-P)(1:50-200)
Crossreactivity Mouse, Rat, Human
Crossreactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background Fos and Jun, In addition to activating cytokine gene transcription, NFAT proteins are activated by increases in intracellular calcium, NFAT proteins are widely expressed and alternatively modified to generate splice variants, NFAT1, NFAT2, NFAT2 is also implicated in cardiac valve development, NFAT5 is detected in both immune and nonimmune cells and, This activating event induces a conformational change in the protein structure that exposes the nuclear localization signal and facilitates the translocation of NFAT proteins from the cytosol into the nucleus, and NFAT2 and NFAT3 are expressed at high levels in cardiac tissues, and NFAT3 is involved in cardiac hypertrophy, and NFAT4 are predominantly expressed in immune cells, and they are localized to both the cytosol (NFATc) and to the nucleus (NFATn), calcineurin, contains a highly conserved Rel-like binding domain that mediates NFAT proteins associating with specific consensus sequences on DNA, dephosphorylating NFAT proteins, like other NFAT proteins, on DNA to regulate cytokine expression in T cells, which leads to the calmodulin-dependent phosphatase, Members of the NFAT (nuclear factor of activated T cells) family of transcription factors are related to NFkB/Rel proteins and form cooperative complexes with the AP-1 proteins
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Excitation Emission512, 550nm/570, 615nm
Synonyms TONEBP KIAA0827 NFATL1 OREBP NFATZ NF-AT5
Properties 1 of the NFAT5 (Ser1197) Antibody, Conjugated can be used in flow cytometry but typically shows lower fluorescence intensity comparable to that of PE or APC, Cy3 antibodies are excited by the 488-nanometer wave of an argon laser and the 633-nanometer line of a helium-neon diode laser, This Bioss Primary Conjugated Antibodies antibody is well suited for fluorescent microscopy, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene targetNFAT5 (Ser1197) Conjugated
Short name Conjugated, NFAT5 (Ser1197) Antibody
Technique antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
LabelCy3
Alternative name cyanine 3 coupled, tonicity-responsive (Ser1197) (Antibody to), nuclear factor on activated T-cells 5
Alternative techniqueantibodies
Alternative to gene target DNA-templated and biological process this GO :0006366 and transcription from RNA polymerase II promoter and biological process this GO :0007165 and signal transduction and biological process this GO :0007588 and excretion and biological process this GO :0010628 and positive regulation of gene expression and biological process this GO :0045087 and innate immune response and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0070884 and regulation of calcineurin-NFAT signaling cascade and biological process, NF-AT5 and NFATL1 and NFATZ and OREBP and TONEBP, NFAT5 and IDBG-39265 and ENSG00000102908 and 10725, NFAT5 and IDBG-634541 and ENSBTAG00000013412 and 538523, Nfat5 and IDBG-190689 and ENSMUSG00000003847 and 54446, nuclei, protein binding, this GO :0001816 and cytokine production and biological process this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006355 and regulation of transcription, this GO :0003677: DNA binding, this GO :0003677: DNA binding and also this GO :0003700: sequence-specific DNA binding transcription factor activity and also this GO :0005515: protein binding, this GO :0003700: sequence-specific DNA binding transcription factor activity, this GO :0005515: protein binding, tonicity-responsive, nuclear factor of activated T-cells 5
Identity 7774
Gene NFAT5
Long gene name nuclear factor of activated T-cells 5
Synonyms gene name nuclear factor of activated T-cells 5, tonicity-responsive
Synonyms name tonicity-responsive enhancer binding protein
Locus 16q22, 1
Discovery year 1999-07-16
GenBank acession AF134870
Entrez gene record 10725
Pubmed identfication 10377394
RefSeq identity NM_138714
Classification Nuclear factors of activated T-cells
Havana BLAST/BLAT OTTHUMG00000137572

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