Filters

NFKB p65(Ser536) Antibody

NFKB p65(Ser536) Antibody size: 0.1ml 281

Supplier BIOSS PRIMARY UNCONJUGATED ANTIBODIES
Price 281
Size 0.1ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
Long nameNFKB p65(Ser536) Primary Polyclonal Antibody
Also known asNFKB p65(Ser536) PAb
CategoryPrimary Antibodies
ConjugationUnconjugated
Target AntigenNFKB p65 Ser536
SpecificityThis is a highly specific antibody against NFKB p65 Ser536
Modification(s)Phosphorylation
Modification site(s)Ser536
ClonalityPolyclonal antibody
Clone numberPolyclonal antibody
Concentration1ug per 1ul
Immunogen range515-551/551
Subcellular location Nucleus, Cytoplasm
SourceKLH conjugated synthetic phosphopeptide derived from human NFKBp65 around the phosphorylation site of(Ser536)
Gene ID number5970
Swiss ProtQ04206
Tested Applications IF(IHC-P), IHC-P, WB
Recommended dilutions IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000)
Cross reactivity Mouse, Rat, Human
Cross reactive species details not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the target antigen Associates with chromatin at the NF-kappa-B promoter region via association with DDX1, Different dimer combinations act as transcriptional activators or repressors, Essential for cytokine gene expression in T-cells (PubMed:15790681), I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, In a conventional activation pathway, NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family, NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators, NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one, RELB, The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression, The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity, The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65, cell growth, differentiation, immunity, p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-kappa-B complex, respectively, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus, tumorigenesis and apoptosis, NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation
Purification methodThis antibody was purified via Protein A
Storage conditions 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA
Synonym names NFKB3, Nuclear factor NF-kappa-B p65 subunit, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, RELA, Transcription factor p65, p65
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24°
Gene targetNFKB p65(Ser536)
Short nameNFKB p65(Ser536) Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameNFKB p65(Ser536) (Antibody to)
Alternative techniqueantibodies

Similar products

Subscribe to our Newsletter