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NFKB2 Antibody

NFKB2 Antibody size: 0.4 ml 406

Supplier NJS POLY
Price 406
Size 0.4 ml
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration pH 7, with 0, 09% sodium azide, 4, In 1X PBS
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenNFKB2
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applications ELISA, WB
Recommended dilutionsWestern blot: 1:1000
NotesTitration of the NFKB2 antibody may be required due to differences in protocols and secondary/substrate sensitivity
Intented useThis NFKB2 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #Q00653
PurityAntigen affinity
Description (1999) [PubMed 9895331] and Baldwin (1996) [PubMed 8717528], C, For reviews, However, In contrast, Inappropriate activation of NF-kappa-B has been linked to inflammatory events associated with autoimmune arthritis, MIM 600664) or IKBKB (MIM 603258) marks them for destruction via the ubiquitination pathway, NF-kappa-B complexes are inhibited by I-kappa-B proteins, NF-kappa-B is activated by a wide variety of stimuli, NFKB1 (MIM 164011) and NFKB2 encode p105 and p100 proteins that are processed to produce the active p50 and p52 NF-kappa-B subunits, NFKBIA (MIM 164008) or NFKBIB (MIM 604495), Other NF-kappa-B complexes, Phosphorylation of serine residues on the I-kappa-B proteins by the kinases IKBKA (CHUK, R is an A or G purine, REL (MIM 164910), RELA, The activated NF-kappa-B complex translocates into the nucleus and binds DNA at kappa-B-binding motifs, The most abundant activated form of NF-kappa-B is a heterodimer of the p50 or p52 subunit bound to the RELA subunit (MIM 164014), and AIDS, and RELB (MIM 604758), and Y is a C or T pyrimidine), and bacterial or viral products, and delayed cell growth, and some acute phase proteins in health and in various disease states, asthma, atherosclerosis, cell adhesion molecules, chemokines, complete and persistent inhibition of NF-kappa-B has been linked directly to apoptosis, consisting of hetero- and homodimers of p50, glomerulonephritis, growth factors, have also been detected, inappropriate immune cell development, inhaled particles, lung fibrosis, or T, oxidant-free radicals, p52, respectively, see Chen et al, septic shock, such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, such as cytokines, the p100 and p105 proteins serve regulatory functions and should not be considered exclusively as precursor forms, thereby allowing activation of the NF-kappa-B complex, ultraviolet irradiation, which inactivate NF-kappa-B by trapping it in the cytoplasm, NF-kappa-B has been detected in numerous cell types that express cytokines
ImmunogenA portion of amino acids 848-874 from the human protein was used as the immunogen for this NFKB2 antibody
Storage Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, Aliquot the NFKB2 antibody and store frozen at -20 deg
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetNFKB2
Short nameNFKB2 Antibody
Technique antibodies against human proteins, antibodies for, Antibody
Alternative namenuclear factor on kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) (Antibody to)
Alternative techniqueantibodies
Alternative to gene target BT, CVID10 and H2TF1 and LYT-10 and LYT10 and NF-kB2 and p100 and p52, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0007165 and signal transduction and biological process this GO :0030198 and extracellular matrix organization and biological process this GO :0032481 and positive regulation of type I interferon production and biological process this GO :0033257 and Bcl3/NF-kappaB2 complex and cellular component this GO :0034134 and toll-like receptor 2 signaling pathway and biological process this GO :0034138 and toll-like receptor 3 signaling pathway and biological process this GO :0034142 and toll-like receptor 4 signaling pathway and biological process this GO :0034146 and toll-like receptor 5 signaling pathway and biological process this GO :0034162 and toll-like receptor 9 signaling pathway and biological process this GO :0034166 and toll-like receptor 10 signaling pathway and biological process this GO :0035666 and TRIF-dependent toll-like receptor signaling pathway and biological process this GO :0038061 and NIK/NF-kappaB signaling and biological process this GO :0038123 and toll-like receptor TLR1:TLR2 signaling pathway and biological process this GO :0038124 and toll-like receptor TLR6:TLR2 signaling pathway and biological process this GO :0045087 and innate immune response and biological process this GO :0048536 and spleen development and biological process this GO :0051092 and positive regulation of NF-kappaB transcription factor activity and biological process, NFKB2 and IDBG-87893 and ENSG00000077150 and 4791, Nfkb2 and IDBG-172544 and ENSMUSG00000025225 and 18034, nuclei, protein binding, this GO :0002224 and toll-like receptor signaling pathway and biological process this GO :0002268 and follicular dendritic cell differentiation and biological process this GO :0002467 and germinal center formation and biological process this GO :0002755 and MyD88-dependent toll-like receptor signaling pathway and biological process this GO :0002756 and MyD88-independent toll-like receptor signaling pathway and biological process this GO :0003677 and DNA binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0003713 and transcription coactivator activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006351 and transcription, this GO :0003677: DNA binding, this GO :0003677: DNA binding and also this GO :0003700: sequence-specific DNA binding transcription factor activity and also this GO :0003713: transcription coactivator activity and also this GO :0005515: protein binding, this GO :0003700: sequence-specific DNA binding transcription factor activity, this GO :0003713: transcription coactivator activity, this GO :0005515: protein binding, 20288 and IDBG-639157 and ENSBTAG00000006017 and 526392, nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Identity 7795
Gene NFKB2
Long gene name nuclear factor kappa B subunit 2
Synonyms gene name nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
Synonyms LYT-10 p52 p105 NF-kB2 p49/p100
Locus 10q24, 32
Discovery year 1991-11-14
GenBank acession X61498
Entrez gene record 4791
Pubmed identfication 1876189
Classification Ankyrin repeat domain containing NF-kappa B complex subunits
Havana BLAST/BLAT OTTHUMG00000018962

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