| Long name | NGFR Primary Polyclonal Antibody |
| Also known as | NGFR PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | NGFR |
| Specificity | This is a highly specific antibody against NGFR |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Immunogen range | 170-220/427 |
| Subcellular location | Extracellular |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NGFR/p75NTR |
| Gene ID number | 4804 |
| Swiss Prot | P08138 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | It is expressed on many neuronal cells types including many embryonic forms and the receptor can be used to isolate neuronal progenitor cells, Its action is mediated by binding to two distinct receptors, NGF is important for the development, NT-4/5, The p75 receptor binds nerve growth factor, The p75NGFR plays an important role in neurotrophic factor signaling and has been shown to modulate the susceptibility of selective cellular populations to programmed cell death, and NT-6, brain-derived neurotrophic factor, differentiation and survival of a variety of neuronal and non-neuronal cells, neurotrophin-3 (NT-3), neurotrophin-3 and neurotrophin-4 with varying specificities, p75NGFR belongs to the TNF-R superfamily and is reported to mediate NGF-induced apoptosis, p75NGFR binds neurotrophins including brain-derived neurotrophic factor (BDNF), p75NGFR interacts with TrkA, the high affinity NGF receptor and potentiates TrkA signaling at low NGF concentrations, the high affinity p140 and low affinity p75, The low affinity NGFR (Nerve growth factor receptor) is a 75kDa membrane-spanning glycoprotein lacking intrinsic tyrosine kinase activity |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | CD271, CD271 antigen, Gp80 LNGFR, Low affinity nerve growth factor receptor, Low affinity nerve growth factor receptor, Low affinity neurotrophin receptor p75NTR, Low affinity neurotrophin receptor p75NTR, NGF receptor, NGF receptor, NGFR, Nerve growth factor receptor, Nerve growth factor receptor TNFR superfamily member 16, TNFR Superfamily Member 16, TNFRSF16, TNR16_HUMAN, Tumor necrosis factor receptor superfamily member 16, ngfrp75, p75 ICD, p75 ICD, p75 NTR, p75 Neurotrophin receptor, Gp80 LNGFR |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | NGFR |
| Short name | NGFR Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | nerve growth factor receptor (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | CD271 and Gp80-LNGFR and p75(NTR) and p75NTR and TNFRSF16, NGFR and IDBG-57653 and ENSG00000064300 and 4804, NGFR and IDBG-638806 and ENSBTAG00000020979 and 353110, Ngfr and IDBG-209608 and ENSMUSG00000000120 and 18053, nerve growth factor binding, nuclei, this GO :0004871 and signal transducer activity and molecular function this GO :0004872 and receptor activity and molecular function this GO :0004888 and transmembrane signaling receptor activity and molecular function this GO :0005035 and death receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005768 and endosome and cellular component this GO :0005829 and cytosol and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006886 and intracellular protein transport and biological process this GO :0007165 and signal transduction and biological process this GO :0007411 and axon guidance and biological process this GO :0007417 and central nervous system development and biological process this GO :0009986 and cell surface and cellular component this GO :0010468 and regulation of gene expression and biological process this GO :0012501 and programmed cell death and biological process this GO :0016048 and detection of temperature stimulus and biological process this GO :0017137 and Rab GTPase binding and molecular function this GO :0021675 and nerve development and biological process this GO :0031069 and hair follicle morphogenesis and biological process this GO :0031293 and membrane protein intracellular domain proteolysis and biological process this GO :0031625 and ubiquitin protein ligase binding and molecular function this GO :0032922 and circadian regulation of gene expression and biological process this GO :0040037 and negative regulation of fibroblast growth factor receptor signaling pathway and biological process this GO :0042488 and positive regulation of odontogenesis of dentin-containing tooth and biological process this GO :0042593 and glucose homeostasis and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043281 and regulation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0043588 and skin development and biological process this GO :0045786 and negative regulation of cell cycle and biological process this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048146 and positive regulation of fibroblast proliferation and biological process this GO :0048406 and nerve growth factor binding and molecular function this GO :0050770 and regulation of axonogenesis and biological process this GO :0050771 and negative regulation of axonogenesis and biological process this GO :0050772 and positive regulation of axonogenesis and biological process this GO :0051799 and negative regulation of hair follicle development and biological process this GO :0097190 and apoptotic signaling pathway and biological process this GO :0097481 and neuronal postsynaptic density and cellular component this GO :2001235 and positive regulation of apoptotic signaling pathway and biological process this GO :2001273 and regulation of glucose import in response to insulin stimulus and biological process, this GO :0004871: signal transducer activity, this GO :0004871: signal transducer activity and also this GO :0004872: receptor activity and also this GO :0004888: transmembrane signaling receptor activity and also this GO :0005035: death receptor activity and also this GO :0005515: protein binding and also this GO :0017137: Rab GTPase binding and also this GO :0031625: ubiquitin protein ligase binding and also this GO :0048406: nerve growth factor binding, this GO :0004872: receptor activity, this GO :0004888: transmembrane signaling receptor activity, this GO :0005035: death receptor activity, this GO :0005515: protein binding, this GO :0017137: Rab GTPase binding, this GO :0031625: ubiquitin protein ligase binding, this GO :0048406: nerve growth factor binding, nerve growth factor receptor |
| Identity | 7809 |
| Gene | NGFR |
| Long gene name | nerve growth factor receptor |
| Synonyms gene name | member 16) , nerve growth factor receptor (TNFR superfamily |
| Synonyms | TNFRSF16 CD271 p75NTR |
| Synonyms name | low affinity nerve growth factor receptor TNFR superfamily, member 16 |
| Locus | 17q21, 33 |
| Discovery year | 2001-06-22 |
| GenBank acession | M14764 |
| Entrez gene record | 4804 |
| Pubmed identfication | 3022937 3006050 |
| Classification | CD molecules Tumor necrosis factor receptor superfamily |
| Havana BLAST/BLAT | OTTHUMG00000161495 |
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