| Long name | 2/NKX2-2 Primary Polyclonal Antibody, Nkx2 |
| Also known as | 2/NKX2-2 PAb, Nkx2 |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | 2/NKX2-2, Nkx2 |
| Specificity | 2/NKX2-2, This is a highly specific antibody against Nkx2 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Source | 2, This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Nkx2 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | During neural development, Homozygous null mutations of the Nkx-2, In the pancreas, Nkx-2, Nkx-2, Nkx-2, Specifically, b and pancreatic polypeptide (PP) cells, but not in d cells, heart and pancreas, including Nkx-2, including brain, including diabetes and cancer, sonic hedgehog (Shh) is known to control cell fate and mitogenesis, the Nkx-2, which is correlated with Shh dose-dependent expression of several genes, which produce insulin, which suggests that Nkx-2, 1, 2 and Nkx-2, 2 expression is required for differentiation of pancreatic b cells, 2 gene in mice lead to severe hyperglycemia and death shortly after birth, 2 is expressed in a, 2 may be an important therapeutic target for pancreatic diseases, 2 protein is responsible for directing ventral neuronal patterning in response to graded Shh signaling, 9, Members of the NK-2 family of homeodomain proteins are key regulators of growth and development in several tissues |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | Homeobox protein NK-2 homolog B, Homeobox protein Nkx 2, Homeobox protein Nkx-2, NK 2 homolog B, NK2 homeobox 2, NK2 transcription factor like protein B, NK2 transcription factor related locus 2, NKX2 2, NKX2-2, NKX22, NKX22_HUMAN, Nkx2b, tinman, 2, 2, Homeobox protein NK 2 homolog B |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | 2/NKX2-2, Nkx2 |
| Short name | 2/NKX2-2 Antibody, Nkx2 |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | 2/NK2 homeobox 2 (Antibody to), Nkx2 |
| Alternative technique | antibodies |
| Alternative to gene target | BT, DNA-templated and biological process this GO :0006355 and regulation of transcription, DNA-templated and biological process this GO :0007224 and smoothened signaling pathway and biological process this GO :0007399 and nervous system development and biological process this GO :0007420 and brain development and biological process this GO :0008134 and transcription factor binding and molecular function this GO :0009749 and response to glucose and biological process this GO :0014003 and oli this GO dendrocyte development and biological process this GO :0014070 and response to organic cyclic compound and biological process this GO :0021522 and spinal cord motor neuron differentiation and biological process this GO :0021529 and spinal cord oli this GO dendrocyte cell differentiation and biological process this GO :0021530 and spinal cord oli this GO dendrocyte cell fate specification and biological process this GO :0021554 and optic nerve development and biological process this GO :0030154 and cell differentiation and biological process this GO :0031018 and endocrine pancreas development and biological process this GO :0032570 and response to progesterone and biological process this GO :0043565 and sequence-specific DNA binding and molecular function this GO :0045595 and regulation of cell differentiation and biological process this GO :0045597 and positive regulation of cell differentiation and biological process this GO :0045665 and negative regulation of neuron differentiation and biological process this GO :0045666 and positive regulation of neuron differentiation and biological process this GO :0045944 and positive regulation of transcription from RNA polymerase II promoter and biological process this GO :0048468 and cell development and biological process this GO :0048565 and digestive tract development and biological process this GO :0048665 and neuron fate specification and biological process this GO :0048708 and astrocyte differentiation and biological process this GO :0048714 and positive regulation of oli this GO dendrocyte differentiation and biological process this GO :0051091 and positive regulation of sequence-specific DNA binding transcription factor activity and biological process this GO :0060580 and ventral spinal cord interneuron fate determination and biological process, NKX2, NKX2-2 and IDBG-59106 and ENSG00000125820 and 4821, Nkx2-2 and IDBG-208906 and ENSMUSG00000027434 and 18088, nuclei, sequence-specific DNA binding, this GO :0001159 and core promoter proximal region DNA binding and molecular function this GO :0003323 and type B pancreatic cell development and biological process this GO :0003326 and pancreatic A cell fate commitment and biological process this GO :0003327 and type B pancreatic cell fate commitment and biological process this GO :0003329 and pancreatic PP cell fate commitment and biological process this GO :0003677 and DNA binding and molecular function this GO :0003682 and chromatin binding and molecular function this GO :0003700 and sequence-specific DNA binding transcription factor activity and molecular function this GO :0003713 and transcription coactivator activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0006351 and transcription, this GO :0001159: core promoter proximal region DNA binding, this GO :0001159: core promoter proximal region DNA binding and also this GO :0003677: DNA binding and also this GO :0003682: chromatin binding and also this GO :0003700: sequence-specific DNA binding transcription factor activity and also this GO :0003713: transcription coactivator activity and also this GO :0005515: protein binding and also this GO :0008134: transcription factor binding and also this GO :0043565: sequence-specific DNA binding, this GO :0003677: DNA binding, this GO :0003682: chromatin binding, this GO :0003700: sequence-specific DNA binding transcription factor activity, this GO :0003713: transcription coactivator activity, this GO :0005515: protein binding, this GO :0008134: transcription factor binding, this GO :0043565: sequence-specific DNA binding, 2 and NKX2B, 48094 and IDBG-639097 and ENSBTAG00000010277 and 531695, NK2 homeobox 2 |
| Identity | 7835 |
| Gene | NKX2-2 |
| Long gene name | NK2 homeobox 2 |
| Synonyms gene | NKX2B |
| Synonyms gene name | NK-2 (Drosophila) homolog B NK2 transcription factor related, locus 2 (Drosophila) |
| Synonyms | NKX2, 2 |
| Locus | 20p11, 22 |
| Discovery year | 1992-06-12 |
| GenBank acession | AF019415 |
| Entrez gene record | 4821 |
| Pubmed identfication | 9703340 1346742 |
| Classification | NKL subclass homeoboxes and pseudogenes |
| Havana BLAST/BLAT | OTTHUMG00000170524 |
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