| Long name | NLGN1/NLGN2 Primary Polyclonal Antibody |
| Also known as | NLGN1/NLGN2 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | NLGN1/NLGN2 |
| Specificity | This is a highly specific antibody against NLGN1/NLGN2 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NLGN1/NLGN2 |
| Gene ID number | 1131 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | Members of the neuroligin family include Neuroligin 1, Neuroexin 1b binds to the EF-hand domain of Neuroligin 1 and requires calcium ion, Neuroligin 2 and Neuroligin 3, Neuroligins also bind to PSD-95, Neuroligins are expressed in excitatory neuronal synaptic clefts, Neuroligins play a role in the formation and remodeling of CNS synapses by binding to b-neurexins, a family of neuronal cell surface proteins, a large esterase homology domain, a short cytoplasmic domain, a single transmembrane region, and an EF-hand binding domain (1, which may recruit ion channels and neurotransmitter receptors to the synapses, 2), Neuroligins are a family of plasma membrane proteins that possess an N-terminal hydrophobic domain |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | NL2, Neuroligin 1, Neuroligin 2, Neuroligin I, Ortholog of human and rat neuroligin 2 NLGN2, NL1 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | NLGN1/NLGN2 |
| Short name | NLGN1/NLGN2 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | neuroligin 1/neuroligin 2 (Antibody to) |
| Alternative technique | antibodies |
| Alternative to gene target | Cell surfaces, Cell surfaces, GABAergic and biological process this GO :0032433 and filopodium tip and cellular component this GO :0035418 and protein localization to synapse and biological process this GO :0042043 and neurexin family protein binding and molecular function this GO :0045184 and establishment of protein localization and biological process this GO :0045202 and synapse and cellular component this GO :0045211 and postsynaptic membrane and cellular component this GO :0045664 and regulation of neuron differentiation and biological process this GO :0046983 and protein dimerization activity and molecular function this GO :0048789 and cytoskeletal matrix organization at active zone and biological process this GO :0050804 and regulation of synaptic transmission and biological process this GO :0050808 and synapse organization and biological process this GO :0050839 and cell adhesion molecule binding and molecular function this GO :0051260 and protein homooli this GO merization and biological process this GO :0051290 and protein heterotetramerization and biological process this GO :0051491 and positive regulation of filopodium assembly and biological process this GO :0051965 and positive regulation of synapse assembly and biological process this GO :0051968 and positive regulation of synaptic transmission, GABAergic and biological process this GO :0035418 and protein localization to synapse and biological process this GO :0035641 and locomotory exploration behavior and biological process this GO :0042043 and neurexin family protein binding and molecular function this GO :0042734 and presynaptic membrane and cellular component this GO :0045202 and synapse and cellular component this GO :0045211 and postsynaptic membrane and cellular component this GO :0045217 and cell-cell junction maintenance and biological process this GO :0050804 and regulation of synaptic transmission and biological process this GO :0050808 and synapse organization and biological process this GO :0050839 and cell adhesion molecule binding and molecular function this GO :0050885 and neuromuscular process controlling balance and biological process this GO :0051965 and positive regulation of synapse assembly and biological process this GO :0051968 and positive regulation of synaptic transmission, NL1, NLGN1 and IDBG-636117 and ENSBTAG00000031891 and 530042, NLGN1 and IDBG-65853 and ENSG00000169760 and 22871, NLGN2 and IDBG-24850 and ENSG00000169992 and 57555, NLGN2 and IDBG-634885 and ENSBTAG00000020252 and 787986, Nlgn1 and IDBG-133960 and ENSMUSG00000063887 and 192167, Nlgn2 and IDBG-192156 and ENSMUSG00000051790 and 216856, cell adhesion molecule binding, cell adhesion molecule binding, glutamatergic and biological process this GO :0060077 and inhibitory synapse and cellular component this GO :0072553 and terminal button organization and biological process this GO :0097104 and postsynaptic membrane assembly and biological process this GO :0097105 and presynaptic membrane assembly and biological process this GO :0097116 and gephyrin clustering and biological process this GO :0097119 and postsynaptic density protein 95 clustering and biological process this GO :0097151 and positive regulation of inhibitory postsynaptic membrane potential and biological process this GO :2000311 and regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity and biological process this GO :2000463 and positive regulation of excitatory postsynaptic membrane potential and biological process, glutamatergic and biological process this GO :0060999 and positive regulation of dendritic spine development and biological process this GO :0072553 and terminal button organization and biological process this GO :0097091 and synaptic vesicle clustering and biological process this GO :0097104 and postsynaptic membrane assembly and biological process this GO :0097105 and presynaptic membrane assembly and biological process this GO :0097113 and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering and biological process this GO :0097114 and N-methyl-D-aspartate receptor clustering and biological process this GO :0097115 and neurexin clustering and biological process this GO :0097119 and postsynaptic density protein 95 clustering and biological process this GO :0097120 and receptor localization to synapse and biological process this GO :0097481 and neuronal postsynaptic density and cellular component this GO :1900029 and positive regulation of ruffle assembly and biological process this GO :1900244 and positive regulation of synaptic vesicle endocytosis and biological process this GO :1902533 and positive regulation of intracellular signal transduction and biological process this GO :2000302 and positive regulation of synaptic vesicle exocytosis and biological process this GO :2000310 and regulation of N-methyl-D-aspartate selective glutamate receptor activity and biological process this GO :2000311 and regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity and biological process this GO :2000463 and positive regulation of excitatory postsynaptic membrane potential and biological process, neuroligin 1, this GO :0002087 and regulation of respiratory gaseous exchange by neurological system process and biological process this GO :0004872 and receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006605 and protein targeting and biological process this GO :0007157 and heterophilic cell-cell adhesion and biological process this GO :0007158 and neuron cell-cell adhesion and biological process this GO :0007399 and nervous system development and biological process this GO :0007416 and synapse assembly and biological process this GO :0008152 and metabolic process and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0009986 and cell surface and cellular component this GO :0016080 and synaptic vesicle targeting and biological process this GO :0016339 and calcium-dependent cell-cell adhesion and biological process this GO :0016787 and hydrolase activity and molecular function this GO :0017146 and N-methyl-D-aspartate selective glutamate receptor complex and cellular component this GO :0023041 and neuronal signal transduction and biological process this GO :0030054 and cell junction and cellular component this GO :0030165 and PDZ domain binding and molecular function this GO :0030425 and dendrite and cellular component this GO :0032230 and positive regulation of synaptic transmission, this GO :0002087 and regulation of respiratory gaseous exchange by neurological system process and biological process this GO :0004872 and receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005887 and integral component of plasma membrane and cellular component this GO :0007158 and neuron cell-cell adhesion and biological process this GO :0007416 and synapse assembly and biological process this GO :0008152 and metabolic process and biological process this GO :0009986 and cell surface and cellular component this GO :0016020 and membrane and cellular component this GO :0016337 and single organismal cell-cell adhesion and biological process this GO :0016787 and hydrolase activity and molecular function this GO :0019233 and sensory perception of pain and biological process this GO :0030054 and cell junction and cellular component this GO :0032230 and positive regulation of synaptic transmission, this GO :0004872: receptor activity, this GO :0004872: receptor activity, this GO :0004872: receptor activity and also this GO :0005515: protein binding and also this GO :0016787: hydrolase activity and also this GO :0030165: PDZ domain binding and also this GO :0042043: neurexin family protein binding and also this GO :0046983: protein dimerization activity and also this GO :0050839: cell adhesion molecule binding, this GO :0004872: receptor activity and also this GO :0005515: protein binding and also this GO :0016787: hydrolase activity and also this GO :0042043: neurexin family protein binding and also this GO :0050839: cell adhesion molecule binding, this GO :0005515: protein binding, this GO :0005515: protein binding, this GO :0016787: hydrolase activity, this GO :0016787: hydrolase activity, this GO :0030165: PDZ domain binding, this GO :0042043: neurexin family protein binding, this GO :0042043: neurexin family protein binding, this GO :0046983: protein dimerization activity, this GO :0050839: cell adhesion molecule binding, this GO :0050839: cell adhesion molecule binding, neuroligin 2 |
| Identity | 14291 |
| Gene | NLGN1 |
| Long gene name | neuroligin 1 |
| Synonyms | KIAA1070 |
| Locus | 3q26, 31 |
| Discovery year | 2001-01-02 |
| GenBank acession | AB028993 |
| Entrez gene record | 22871 |
| Pubmed identfication | 10767552 10819331 |
| RefSeq identity | NM_014932 |
| Havana BLAST/BLAT | OTTHUMG00000157005 |
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