| Category | Antibody |
| Concentration | 2ml sterile DI water, 5mg/ml if reconstituted with 0 |
| Form | Antigen affinity purified |
| Conjugation | Unconjugated |
| Clone | Polyclonal antibody |
| Recognised antigen | NOS2 |
| Host animal | Rabbit (Oryctolagus cuniculus) |
| Clonality | Polyclonal (rabbit origin) |
| Species reactivity | Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens) |
| Tested applications | WB |
| Recommended dilutions | 5-1ug/ml, Western blot: 0 |
| Notes | Titration of the NOS2 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts |
| Intented use | This NOS2 antibodyis to be used only for research purposes and not for diagnostics |
| Uniprot # | P35228 |
| Purity | Antigen affinity |
| Description | -1173C-T(163730, And conclude that NOS2-derived NO is a prerequisite for cytokine signaling and function in innate immunity, Diefenbach et al, From studies in Tanzania and Kenya, Hobbs et al, In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter, Nitric oxide(NO) is a messenger molecule with diverse functions throughout the body, The human iNOS (NOS2) gene is approximately 37 kb in length and consists of 26 exons and 25 introns, The inducible NOS(iNOS) isoform is expressed in a variety of cell types and tissues in response to inflammatory agents and cytokines, Three different NOS isoforms have been identified which fall into two distinct types, and penile erection, constitutive and inducible, in the NOS2 promoter that was significantly associated with protection from symptomatic malaria and severe malarial anemia, including peristalsis, inducible is an enzyme that in humans is encoded by the NOS2 gene, it is implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, (1999) studied the relationship of IL12 and nitric oxide synthase-2 to innate immunity to the parasite Leishmania in mice, (2002) identified a novel single-nucleotide polymorphism, 0001), Nitric oxide synthase |
| Immunogen | Amino acids 3-24 (CPWKFLFKTKFHQYAMNGEKDI-human) were used as the immunogen for this NOS2 antibody |
| Storage | Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the NOS2 antibody can be stored for up to one month at 4oC, After reconstitution |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24° |
| Gene target | NOS2 |
| Short name | NOS2 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | inducible (Antibody to), nitric oxide synthase 2 |
| Alternative technique | antibodies |
| Alternative to gene target | HEP-NOS and INOS and NOS and NOS2A, NADP binding, NOS2 and IDBG-36000 and ENSG00000007171 and 4843, NOS2 and IDBG-631501 and ENSBTAG00000006894 and 282876, Nos2 and IDBG-203203 and ENSMUSG00000020826 and 18126, inducible, nuclei, this GO :0001666 and response to hypoxia and biological process this GO :0001912 and positive regulation of leukocyte mediated cytotoxicity and biological process this GO :0002227 and innate immune response in mucosa and biological process this GO :0003958 and NADPH-hemoprotein reductase activity and molecular function this GO :0004517 and nitric-oxide synthase activity and molecular function this GO :0005102 and receptor binding and molecular function this GO :0005506 and iron ion binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005516 and calmodulin binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005777 and peroxisome and cellular component this GO :0005829 and cytosol and cellular component this GO :0006527 and arginine catabolic process and biological process this GO :0006801 and superoxide metabolic process and biological process this GO :0006809 and nitric oxide biosynthetic process and biological process this GO :0006954 and inflammatory response and biological process this GO :0007263 and nitric oxide mediated signal transduction and biological process this GO :0007596 and blood coagulation and biological process this GO :0007623 and circadian rhythm and biological process this GO :0009617 and response to bacterium and biological process this GO :0010181 and FMN binding and molecular function this GO :0010629 and negative regulation of gene expression and biological process this GO :0016491 and oxidoreductase activity and molecular function this GO :0018119 and peptidyl-cysteine S-nitrosylation and biological process this GO :0020037 and heme binding and molecular function this GO :0030863 and cortical cytoskeleton and cellular component this GO :0031284 and positive regulation of guanylate cyclase activity and biological process this GO :0032496 and response to lipopolysaccharide and biological process this GO :0034617 and tetrahydrobiopterin binding and molecular function this GO :0034618 and arginine binding and molecular function this GO :0042127 and regulation of cell proliferation and biological process this GO :0042177 and negative regulation of protein catabolic process and biological process this GO :0042742 and defense response to bacterium and biological process this GO :0042803 and protein homodimerization activity and molecular function this GO :0043457 and regulation of cellular respiration and biological process this GO :0045087 and innate immune response and biological process this GO :0045776 and negative regulation of blood pressure and biological process this GO :0045909 and positive regulation of vasodilation and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0050660 and flavin adenine dinucleotide binding and molecular function this GO :0050661 and NADP binding and molecular function this GO :0050796 and regulation of insulin secretion and biological process this GO :0050829 and defense response to Gram-negative bacterium and biological process this GO :0051701 and interaction with host and biological process this GO :0051712 and positive regulation of killing of cells of other organism and biological process this GO :0055114 and oxidation-reduction process and biological process this GO :0071222 and cellular response to lipopolysaccharide and biological process this GO :0071346 and cellular response to interferon-gamma and biological process this GO :0090382 and pha this GO some maturation and biological process, this GO :0003958: NADPH-hemoprotein reductase activity, this GO :0003958: NADPH-hemoprotein reductase activity and also this GO :0004517: nitric-oxide synthase activity and also this GO :0005102: receptor binding and also this GO :0005506: iron ion binding and also this GO :0005515: protein binding and also this GO :0005516: calmodulin binding and also this GO :0010181: FMN binding and also this GO :0016491: oxidoreductase activity and also this GO :0020037: heme binding and also this GO :0034617: tetrahydrobiopterin binding and also this GO :0034618: arginine binding and also this GO :0042803: protein homodimerization activity and also this GO :0050660: flavin adenine dinucleotide binding and also this GO :0050661: NADP binding, this GO :0004517: nitric-oxide synthase activity, this GO :0005102: receptor binding, this GO :0005506: iron ion binding, this GO :0005515: protein binding, this GO :0005516: calmodulin binding, this GO :0010181: FMN binding, this GO :0016491: oxidoreductase activity, this GO :0020037: heme binding, this GO :0034617: tetrahydrobiopterin binding, this GO :0034618: arginine binding, this GO :0042803: protein homodimerization activity, this GO :0050660: flavin adenine dinucleotide binding, this GO :0050661: NADP binding, nitric oxide synthase 2 |
| Identity | 23292 |
| Gene | NANOS2 |
| Long gene name | nanos C2HC-type zinc finger 2 |
| Synonyms gene name | nanos homolog 2 (Drosophila) |
| Synonyms | NOS2 ZC2HC12B |
| Locus | 19q13, 32 |
| Discovery year | 2003-12-01 |
| GenBank acession | BC042883 |
| Entrez gene record | 339345 |
| Pubmed identfication | 12947200 12690449 |
| Classification | Zinc fingers C2HC-type |
| Havana BLAST/BLAT | OTTHUMG00000182487 |
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