| Long name | NPC1 Primary Polyclonal Antibody |
| Also known as | NPC1 PAb |
| Category | Primary Antibodies |
| Conjugation | Unconjugated |
| Target Antigen | NPC1 |
| Specificity | This is a highly specific antibody against NPC1 |
| Modification(s) | None |
| Modification site(s) | Unmodified antibody |
| Clonality | Polyclonal antibody |
| Clone number | Polyclonal antibody |
| Concentration | 1ug per 1ul |
| Source | This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NPC1/Niemann Pick C1 |
| Gene ID number | 4864 |
| Tested Applications | IF(IHC-P), IHC-P, WB |
| Recommended dilutions | IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity | Mouse, Rat, Human |
| Cross reactive species details | not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen | 13 transmembrane domains, Aug 2009], Defects in this gene cause Niemann-Pick type C disease, It is predicted to have a cytoplasmic C-terminus, This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus, This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain, [provided by RefSeq |
| Purification method | This antibody was purified via Protein A |
| Storage conditions | 50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names | NPC, NPC1, NPC1_HUMAN, Niemann Pick C1 protein precursor, Niemann Pick disease, Niemann-Pick C1 protein, type C1, Niemann Pick C1 |
| Properties | C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target | NPC1 |
| Short name | NPC1 Antibody |
| Technique | antibodies against human proteins, antibodies for, Antibody |
| Alternative name | classification C1 (Antibody to), Niemann-Pick disease |
| Alternative technique | antibodies |
| Alternative to gene target | NPC, NPC1 and IDBG-1600 and ENSG00000141458 and 4864, NPC1 and IDBG-643938 and ENSBTAG00000015195 and 286772, Npc1 and IDBG-128877 and ENSMUSG00000024413 and 18145, cholesterol binding, nuclei, this GO :0004872 and receptor activity and molecular function this GO :0004888 and transmembrane signaling receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005576 and extracellular region and cellular component this GO :0005635 and nuclear envelope and cellular component this GO :0005764 and lysosome and cellular component this GO :0005765 and lysosomal membrane and cellular component this GO :0005768 and endosome and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005794 and this GO lgi apparatus and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006486 and protein glycosylation and biological process this GO :0006897 and endocytosis and biological process this GO :0006914 and autophagy and biological process this GO :0007041 and lysosomal transport and biological process this GO :0007165 and signal transduction and biological process this GO :0007628 and adult walking behavior and biological process this GO :0008158 and hedgehog receptor activity and molecular function this GO :0008203 and cholesterol metabolic process and biological process this GO :0008206 and bile acid metabolic process and biological process this GO :0015248 and sterol transporter activity and molecular function this GO :0015485 and cholesterol binding and molecular function this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016242 and negative regulation of macroautophagy and biological process this GO :0030301 and cholesterol transport and biological process this GO :0031579 and membrane raft organization and biological process this GO :0031902 and late endosome membrane and cellular component this GO :0031982 and vesicle and cellular component this GO :0033344 and cholesterol efflux and biological process this GO :0042493 and response to drug and biological process this GO :0042632 and cholesterol homeostasis and biological process this GO :0045121 and membrane raft and cellular component this GO :0046686 and response to cadmium ion and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0060548 and negative regulation of cell death and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071383 and cellular response to steroid hormone stimulus and biological process this GO :0071404 and cellular response to low-density lipoprotein particle stimulus and biological process this GO :0090150 and establishment of protein localization to membrane and biological process, this GO :0004872: receptor activity, this GO :0004872: receptor activity and also this GO :0004888: transmembrane signaling receptor activity and also this GO :0005515: protein binding and also this GO :0008158: hedgehog receptor activity and also this GO :0015248: sterol transporter activity and also this GO :0015485: cholesterol binding, this GO :0004888: transmembrane signaling receptor activity, this GO :0005515: protein binding, this GO :0008158: hedgehog receptor activity, this GO :0015248: sterol transporter activity, this GO :0015485: cholesterol binding, type C1, Niemann-Pick disease |
| Identity | 7897 |
| Gene | NPC1 |
| Long gene name | NPC intracellular cholesterol transporter 1 |
| Synonyms gene name | Niemann-Pick disease, type C1 |
| Locus | 18q11, 2 |
| Discovery year | 1993-04-13 |
| GenBank acession | AF002020 |
| Entrez gene record | 4864 |
| Pubmed identfication | 8446622 |
| RefSeq identity | NM_000271 |
| Havana BLAST/BLAT | OTTHUMG00000131873 |
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