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NPHS2 Antibody (Podocin)

NPHS2 Antibody (Podocin) size: 0.1mg 389

Supplier NJS POLY
Price 389
Size 0.1mg
Contact us Ask Component cell markers and DNA bp. markers are genetic markerser genes or DNA sequenceswith selection audit
CategoryAntibody
Concentration2ml sterile DI water, 5mg/ml if reconstituted with 0
FormAntigen affinity purified
ConjugationUnconjugated
ClonePolyclonal antibody
Recognised antigenNPHS2 (Podocin)
Host animalRabbit (Oryctolagus cuniculus)
ClonalityPolyclonal (rabbit origin)
Species reactivity Due to limited knowledge and inability to test the antibody against all known species, Mouse (Mus musculus), Rat , we cannot guarantee that no other cross reactivity can occur, Human (Homo sapiens)
Tested applicationsWB
Recommended dilutions5-1ug/ml, Western blot: 0
Notes Titration of the NPHS2 antibody may be required due to differences in protocols and secondary/substrate sensitivity, The stated application concentrations are suggested starting amounts
Intented useThis NPHS2 antibodyis to be used only for research purposes and not for diagnostics
Uniprot #Q9NP85
PurityAntigen affinity
Description Boute et al, By positional cloning, It is almost exclusively expressed in the podocytes of fetal and mature kidney glomeruli, NPHS2 is a causative gene for Familial idiopathic nephrotic syndromes, also called Podocin (PDCN), and encodes a new integral membrane protein, and include autosomal recessive steroid-resistant nephrotic syndrome, belonging to the stomatin protein family, comprising nonsense, demonstrating a crucial role for podocin in the function of the glomerular filtration barrier, frameshift and missense mutations, is a protein which lines the podocytes and assists in maintaining the barrier at the glomerular basement membrane, it was mapped to 1q25-31, podocin, rapid progression to end-stage renal disease and focal segmental glomerulosclerosis, to segregate with the disease, which is characterized by early childhood onset of proteinuria, which represents a heterogeneous group of kidney disorders, (2000) found ten different NPHS2 mutations, NPHS2
ImmunogenAn amino acid sequence from the middle region of human NPHS2 (CVKVVQEYERVIIFRLGH) was used as the immunogen for this NPHS2 antibody
Storage Avoid repeated freezing and thawing, Celcius or lower, Cycles of freezing and thawing can denaturate the peptide chains of the antibodies and reduce their sensitivity and/or change their affinity, For long-term, Prepare aliqotes in such a manner so that freeze-thaw cycles are minimized, aliquot and store at -20 deg, the NPHS2 antibody can be stored for up to one month at 4oC, After reconstitution
PropertiesC, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by NJS poly they should be stored frozen at - 24°
Gene targetNPHS2 (Podocin)
Short nameNPHS2 Antibody (Podocin)
Technique antibodies against human proteins, antibodies for, Antibody
Alternative nameNPHS2 (Antibody to) (Podocin)
Alternative techniqueantibodies
Identity 13394
Gene NPHS2
Long gene name NPHS2, podocin
Synonyms gene name idiopathic, nephrosis 2, steroid-resistant (podocin)
Synonyms SRN1 PDCN
Locus 1q25, 2
Discovery year 2000-11-21
GenBank acession AJ279254
Entrez gene record 7827
Pubmed identfication 8589695 10742096
Havana BLAST/BLAT OTTHUMG00000035252
Locus Specific Databases LRG_887

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